Source:http://linkedlifedata.com/resource/pubmed/id/17143548
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2006-12-4
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| pubmed:abstractText |
The phosphatidylethanolamine (PE)-binding protein (PEBP) family is an evolutionary conserved group of proteins found in various species with multiple functions. We identified human PE-binding protein 4 (hPEBP4), a novel member of the PEBP family, as an anti-apoptotic molecule. Here we describe the cloning and functional characterization of the mouse homolog of hPEBP4 (mouse PEBP4, mPEBP4). Full-length cDNA of mPEBP4 contains 1048 bp with an open reading frame (ORF) of 729 bp, which is predicted to encode a 242-aa protein. mPEBP4 contains a PE-binding domain, in this case between amino acids 106 and 213. mPEBP4 localizes primarily to endoplasmic reticulum/Golgi apparatus. Interestingly, RT-PCR and in situ hybridization analyses indicate that mPEBP4 is specifically expressed in mouse eye tissue. We demonstrate that mPEBP4 promotes cellular migration and invasion by inhibiting ERK1/2 and JNK activation and up-regulating the expression of COX-2. In addition, mPEBP4 overexpression inhibits Epirubicin-induced cellular apoptosis. Considering that mPEBP4 is specifically expressed in retinal ganglion cells, whether mPEBP4 is an important molecule involved in visual function needs to be further investigated.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2,
http://linkedlifedata.com/resource/pubmed/chemical/Epirubicin,
http://linkedlifedata.com/resource/pubmed/chemical/MAP Kinase Kinase 4,
http://linkedlifedata.com/resource/pubmed/chemical/Mitogen-Activated Protein Kinase 3,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphatidylethanolamine Binding...,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1107-3756
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
19
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
55-63
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| pubmed:dateRevised |
2009-11-19
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| pubmed:meshHeading |
pubmed-meshheading:17143548-Amino Acid Sequence,
pubmed-meshheading:17143548-Animals,
pubmed-meshheading:17143548-Apoptosis,
pubmed-meshheading:17143548-Carrier Proteins,
pubmed-meshheading:17143548-Cell Movement,
pubmed-meshheading:17143548-Cells, Cultured,
pubmed-meshheading:17143548-Cloning, Molecular,
pubmed-meshheading:17143548-Cyclooxygenase 2,
pubmed-meshheading:17143548-Epirubicin,
pubmed-meshheading:17143548-Eye,
pubmed-meshheading:17143548-MAP Kinase Kinase 4,
pubmed-meshheading:17143548-Mice,
pubmed-meshheading:17143548-Mitogen-Activated Protein Kinase 3,
pubmed-meshheading:17143548-Molecular Sequence Data,
pubmed-meshheading:17143548-Phosphatidylethanolamine Binding Protein,
pubmed-meshheading:17143548-RNA, Messenger,
pubmed-meshheading:17143548-Sequence Homology, Amino Acid,
pubmed-meshheading:17143548-Up-Regulation
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| pubmed:year |
2007
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| pubmed:articleTitle |
Promotion of cellular migration and apoptosis resistance by a mouse eye-specific phosphatidylethanolamine-binding protein.
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| pubmed:affiliation |
Institute of Immunology, Zhejiang University, Hangzhou 310031, PR China.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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