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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-12-4
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pubmed:abstractText |
Beta-blockers are widely used and effective for treating hypertension, acute myocardial infarction (MI) and heart failure, but they present side-effects mainly due to antagonism of beta2-adrenergic receptor (AR). Currently available beta-blockers are at best selective but not specific for beta1 or beta2-AR.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0263-6352
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
25
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
197-205
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pubmed:dateRevised |
2007-12-3
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pubmed:meshHeading |
pubmed-meshheading:17143192-Animals,
pubmed-meshheading:17143192-Antihypertensive Agents,
pubmed-meshheading:17143192-Apoptosis,
pubmed-meshheading:17143192-Blood Pressure,
pubmed-meshheading:17143192-Cell Line, Tumor,
pubmed-meshheading:17143192-Disease Models, Animal,
pubmed-meshheading:17143192-Heart Ventricles,
pubmed-meshheading:17143192-Hypertension,
pubmed-meshheading:17143192-Male,
pubmed-meshheading:17143192-Mice,
pubmed-meshheading:17143192-Myocardial Ischemia,
pubmed-meshheading:17143192-Myocardium,
pubmed-meshheading:17143192-RNA, Messenger,
pubmed-meshheading:17143192-RNA, Small Interfering,
pubmed-meshheading:17143192-RNA Interference,
pubmed-meshheading:17143192-Rats,
pubmed-meshheading:17143192-Rats, Inbred SHR,
pubmed-meshheading:17143192-Rats, Wistar,
pubmed-meshheading:17143192-Receptors, Adrenergic, beta-1,
pubmed-meshheading:17143192-Time Factors,
pubmed-meshheading:17143192-Transfection,
pubmed-meshheading:17143192-Ventricular Function, Left
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pubmed:year |
2007
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pubmed:articleTitle |
Specific beta1-adrenergic receptor silencing with small interfering RNA lowers high blood pressure and improves cardiac function in myocardial ischemia.
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pubmed:affiliation |
Children's Research Institute, Department of Pediatrics, University of South Florida, Saint Petersburg, FL 33701, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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