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pubmed:abstractText |
Mitosis depends upon the cooperative action of multiple microtubule (MT)-based motors. Among these, a kinesin-5, KLP61F, and the kinesin-14, Ncd, are proposed to generate antagonistic-sliding forces that control the spacing of the spindle poles. We tested whether purified KLP61F homotetramers and Ncd homodimers can generate a force balance capable of maintaining a constant spindle length in Drosophila embryos.
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pubmed:affiliation |
Laboratory of Cell and Computational Biology, Center for Genetics and Development, University of California, Davis, Davis, California 95616, USA.
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