Linked Life Data

17139674

Source:http://linkedlifedata.com/resource/pubmed/id/17139674

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
12
pubmed:dateCreated
2006-12-12
pubmed:abstractText
N-Ethylmaleimide sensitive factor (NSF) is an ATPase whose activity is important for intracellular trafficking. Previous genetic analysis of Drosophila NSF2 revealed a potential link between NSF and the actin cytoskeleton. The present study was therefore undertaken to specifically examine genetic interactions between the cytoskeleton and NSF. First, we tested for loss-of-function interaction and, indeed, we found that the combination of flies heterozygous for Act5C and NSF2 alleles led to reduced viability. Second, we expanded our gain-of-function approach to include cytoskeletal genes that were not included in our previous screen. Thirteen of 30 genes tested were found to suppress neuromuscular junction (NMJ) overgrowth. Altogether, these data support the idea that diverse NSF2 developmental and physiological phenotypes are related to disruption of the cytoskeleton and the large number of genes which can partially restore NMJ overgrowth and suggests that NSF may function near the top of the actin regulatory pathway.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1526-954X
pubmed:author
pubmed:copyrightInfo
(c) 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:volume
44
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
595-600
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Interaction of cytoskeleton genes with NSF2-induced neuromuscular junction overgrowth.
pubmed:affiliation
Department of Biology, Tokyo Metropolitan University, Tokyo, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't