Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1991-9-11
pubmed:abstractText
Recently it has been demonstrated that the CD14 molecule which is expressed on monocytes and macrophages serves as a receptor for lipopolysaccharide (LPS) bound to LPS-binding protein (LBP) and thus mediates LPS-induced tumour necrosis factor (TNF) production. Here we report that CD14 is found as a soluble (s) molecule in serum. In healthy volunteers sCD14 levels (mean +/- s.e.m.) were 3.7 +/- 0.05 micrograms/ml (n = 30, 25-50 years of age) as determined by ELISA (detection limit 20 ng/ml serum) using two monoclonal antibodies in a sandwich technique. In polytraumatized patients (n = 16) significantly decreased levels (1.7 +/- 0.3) were detected immediately after the trauma, which increased to 4.9 +/- 0.3 micrograms/ml within the first 6 days post trauma. sCD14 remained elevated during the first 14 days post trauma in patients with the most severe injuries (injury severity score greater than 45 points), whereas a return to normal levels was observed in patients with an injury score of less than 45 points. In addition, the levels of the high-density lipoproteins that partially inactivate free endotoxin are significantly decreased post trauma. No correlation between parameters of inflammation (C3a and neopterin levels, leucocyte counts, amount of band cells), liver function and sCD14 levels was established. Comparable to polytraumatized patients, increased sCD14 serum levels were observed in five patients with burn trauma (burned area greater than 35%) within the second week post trauma when clinical signs of septicaemia were evident.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-1095497, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-1689668, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-1698311, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2154525, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2199284, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2258972, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-227936, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2297191, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2402637, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2412965, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2468604, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2471708, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2540344, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2540776, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2569162, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-2835680, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3255346, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3290526, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3384955, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3493149, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3542580, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-3555304, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-4027746, http://linkedlifedata.com/resource/pubmed/commentcorrection/1713813-4814394
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
0009-9104
pubmed:author
pubmed:issnType
Print
pubmed:volume
85
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
297-301
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
Serum CD14 levels in polytraumatized and severely burned patients.
pubmed:affiliation
Ruhr University, Bochum, Germany.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't