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rdf:type |
|
|
lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
A novel class of furan-based compounds as potential 20S proteasome inhibitors have been designed and synthesized, among which nine compounds are peptide derivatives and six molecules are statine peptidomimetics. The C-terminal furanyl moiety was introduced to target molecules as furan-based amino acids. All the compounds were obtained steadily with moderate to high yield. Compound 12 was a selective moderate potent proteasome peptidomimetic inhibitor. It inhibited HepG2 and HL-60 proliferation effectively.
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pubmed:language |
eng
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pubmed:journal |
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|
pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:day |
15
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|
pubmed:volume |
17
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|
pubmed:owner |
NLM
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|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1102-6
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17134894-Amino Acids,
pubmed-meshheading:17134894-Antineoplastic Agents,
pubmed-meshheading:17134894-Cell Line, Tumor,
pubmed-meshheading:17134894-Chemistry, Physical,
pubmed-meshheading:17134894-Chymotrypsin,
pubmed-meshheading:17134894-Drug Design,
pubmed-meshheading:17134894-Drug Screening Assays, Antitumor,
pubmed-meshheading:17134894-Furans,
pubmed-meshheading:17134894-Humans,
pubmed-meshheading:17134894-Magnetic Resonance Spectroscopy,
pubmed-meshheading:17134894-Mass Spectrometry,
pubmed-meshheading:17134894-Models, Molecular,
pubmed-meshheading:17134894-Physicochemical Phenomena,
pubmed-meshheading:17134894-Proteasome Endopeptidase Complex
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pubmed:year |
2007
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|
pubmed:articleTitle |
Design and synthesis of a novel class of furan-based molecules as potential 20S proteasome inhibitors.
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|
pubmed:affiliation |
Department of Medicinal Chemistry, State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, PR China.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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