Linked Life Data

17131345

Source:http://linkedlifedata.com/resource/pubmed/id/17131345

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2007-1-25
pubmed:abstractText
Individual variations in the ability to cope with DNA damage by DNA repair may be essential for the response to chemotherapy, since cancer cells from patients with an effective DNA repair may survive treatment. We have studied the effect on time to treatment failure (TTF) and overall survival (OS) of polymorphism in the DNA repair genes ERCC1, ERCC2 and XRCC3, and in the apoptotic genes PPP1R13L and CD3EAP in 348 patients with multiple myeloma undergoing autologous bone marrow transplantation. Carriers of the variant C-allele of ERCC2 K751Q, the variant T-allele of XRCC3 T241M and the variant A-allele of CD3EAP G-21A had a 1.3-fold, 1.8-fold and 1.9-fold longer TTF, respectively, than homozygous wild type carriers (p = 0.006, p = 0.004, p < 0.001). The polymorphism CD3EAP G-21A also had significant effect on OS (p < 0.045). The polymorphism ERCC2 K751Q may to be related to sex, since the prolonged TTF was only seen in women (p = 0.001). Carriers of the combination of variant alleles of ERCC2 K751Q and XRCC3 T241M had 2.8-fold longer TTF (p = 0.0002). This indicates that suboptimal repair of both DNA mechanisms favors prolonged TTF and that polymorphism in ERCC2, XRCC3 and CD3EAP predicts the outcome for patients treated with autologous stem cell transplantation.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0020-7136
pubmed:author
pubmed:copyrightInfo
Copyright 2006 Wiley-Liss, Inc.
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
120
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1036-45
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed-meshheading:17131345-Aged, pubmed-meshheading:17131345-Alleles, pubmed-meshheading:17131345-Bone Marrow Transplantation, pubmed-meshheading:17131345-DNA-Binding Proteins, pubmed-meshheading:17131345-Denmark, pubmed-meshheading:17131345-Female, pubmed-meshheading:17131345-Humans, pubmed-meshheading:17131345-Intracellular Signaling Peptides and Proteins, pubmed-meshheading:17131345-Male, pubmed-meshheading:17131345-Middle Aged, pubmed-meshheading:17131345-Multiple Myeloma, pubmed-meshheading:17131345-Multivariate Analysis, pubmed-meshheading:17131345-Polymorphism, Single Nucleotide, pubmed-meshheading:17131345-Transplantation, Autologous, pubmed-meshheading:17131345-Treatment Outcome, pubmed-meshheading:17131345-Tumor Markers, Biological, pubmed-meshheading:17131345-Xeroderma Pigmentosum Group D Protein
pubmed:year
2007
pubmed:articleTitle
Polymorphisms in the genes ERCC2, XRCC3 and CD3EAP influence treatment outcome in multiple myeloma patients undergoing autologous bone marrow transplantation.
pubmed:affiliation
Department of Haematology, Herlev University Hospital of Copenhagen, DK-2730 Herlev, Denmark. anevan01@herlevhosp.kbhamt.dk
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't, Multicenter Study