Linked Life Data

17130566

Source:http://linkedlifedata.com/resource/pubmed/id/17130566

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2006-11-28
pubmed:abstractText
Type 1 diabetes is a polygenic disease with a major susceptibility locus, IDDM1, located in the human leukocyte antigen (HLA) region. Although class II loci, DR and DQ genes in particular, are major components of IDDM1, accumulating lines of evidence indicated that IDDM1 consists of multiple components and that non-class II genes in addition to class II genes contribute to susceptibility to and/or age-at-onset of type 1 diabetes. To identify a second component of IDDM1, we investigated the association of a panel of polymorphisms in 2.2 Mb region of the HLA encompassing from class II to class I regions with type 1 diabetes. Polymorphisms types were: DRB1 and DQB1 in class II; two microsatellite markers, BAT2-GT and TNFa in class III; and, five microsatellite markers, STR-MICA, MIB, C1-3-1, C2-4-4, and C3-2-10 in class I region. A total of >200 Japanese patients and healthy control subjects were studied. Class II DRB1*0405 and DQB1*0401 were significantly associated with susceptibility to, but not with age-at-onset of, type 1 diabetes. C1-3-1, located near C locus, was significantly associated with not only susceptibility to, but also age-at-onset of type 1 diabetes. These data suggest that a second component of IDDM1 maps to the HLA class I region, contributing to susceptibility to as well as age-at-onset of type 1 diabetes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0077-8923
pubmed:author
pubmed:issnType
Print
pubmed:volume
1079
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
278-84
pubmed:meshHeading
pubmed-meshheading:17130566-Age of Onset, pubmed-meshheading:17130566-Alleles, pubmed-meshheading:17130566-Case-Control Studies, pubmed-meshheading:17130566-Chromosome Mapping, pubmed-meshheading:17130566-Diabetes Mellitus, Type 1, pubmed-meshheading:17130566-Gene Frequency, pubmed-meshheading:17130566-Genetic Markers, pubmed-meshheading:17130566-Genetic Predisposition to Disease, pubmed-meshheading:17130566-HLA Antigens, pubmed-meshheading:17130566-HLA-DQ Antigens, pubmed-meshheading:17130566-HLA-DR Antigens, pubmed-meshheading:17130566-Histocompatibility Antigens Class I, pubmed-meshheading:17130566-Humans, pubmed-meshheading:17130566-Japan, pubmed-meshheading:17130566-Microsatellite Repeats, pubmed-meshheading:17130566-Polymorphism, Genetic, pubmed-meshheading:17130566-Polymorphism, Restriction Fragment Length
pubmed:year
2006
pubmed:articleTitle
A second component of HLA-linked susceptibility to type 1 diabetes maps to class I region.
pubmed:affiliation
Department of Endocrinology, Metabolism and Diabetes, Kinki University School of Medicine, 377-2 Ohno-higashi, Osaka-Sayama, Osaka 589-8511, Japan.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't