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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-28
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pubmed:abstractText |
Studies in rodent models have suggested that reduction in renal transforming growth factor (TGF)-beta1 may underlie the renoprotective effects of the renin-angiotensin system (RAS) blockade. However, the role of the RAS blockade in abrogating TGF-beta in human disease is unknown. Accordingly, we sought to examine TGF-beta gene expression and biological activity in human renal biopsies, before and after ACE inhibition.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0149-5992
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2670-5
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pubmed:meshHeading |
pubmed-meshheading:17130203-Adult,
pubmed-meshheading:17130203-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:17130203-DNA Primers,
pubmed-meshheading:17130203-Diabetes Mellitus, Type 2,
pubmed-meshheading:17130203-Diabetic Nephropathies,
pubmed-meshheading:17130203-Female,
pubmed-meshheading:17130203-Gene Expression Regulation,
pubmed-meshheading:17130203-Humans,
pubmed-meshheading:17130203-Kidney,
pubmed-meshheading:17130203-Male,
pubmed-meshheading:17130203-Middle Aged,
pubmed-meshheading:17130203-Perindopril,
pubmed-meshheading:17130203-Phosphorylation,
pubmed-meshheading:17130203-Polymerase Chain Reaction,
pubmed-meshheading:17130203-RNA,
pubmed-meshheading:17130203-Smad2 Protein,
pubmed-meshheading:17130203-Transforming Growth Factor beta
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pubmed:year |
2006
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pubmed:articleTitle |
Transforming growth factor-beta in human diabetic nephropathy: effects of ACE inhibition.
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pubmed:affiliation |
University of Melbourne, Department of Medicine, St. Vincent's Hospital, Australia. rlangham@medstv.unimelb.edu.au
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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