Source:http://linkedlifedata.com/resource/pubmed/id/17129836
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
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| pubmed:dateCreated |
2006-11-28
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| pubmed:abstractText |
Gram-negative bacilli antimicrobial resistance remains a significant problem for patients in the intensive care unit (ICU). We performed a retrospective analysis of microbiological data and antibiotic consumption over a 4-year period (2000-2003) in an Italian ICU. Pseudomonas aeruginosa and Klebsiella pneumoniae represented approximately 40% of all isolates. The most significant trend in antimicrobial use was an increase in use of 3(rd )generation cephalosporins, imipenem, and ciprofloxacin. A significant trend toward an increase in resistance rates to piperacillin, 3( rd )generation cephalosporins and ciprofloxacin was observed for K. pneumoniae and a positive correlation between resistance and drug-usage was evident for K. pneumoniae and piperacillin, cefotaxime, ceftazidime, cefepime, and ciprofloxacin, but not for piperacillin/tazobactam. No statistically significant correlations were evidenced for P. aeruginosa. Trends in resistances were studied also for Serratia spp and Proteus spp. Isolation rates of extended-spectrum beta-lactamase (ESBL)-producing strains in pathogens studied were high, especially for K. pneumoniae (72%, 160/222) and Proteus spp (41%, 18/43). In conclusion, the study showed high resistance among Gram-negative organisms isolated in the ICU and significant ESBL production. A significant correlation between antibiotic consumption and increasing resistance was evident for K. pneumoniae.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
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| pubmed:month |
Jun
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| pubmed:issn |
1973-9478
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| pubmed:author | |
| pubmed:issnType |
Electronic
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
261-7
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| pubmed:dateRevised |
2009-11-3
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| pubmed:meshHeading |
pubmed-meshheading:17129836-Anti-Bacterial Agents,
pubmed-meshheading:17129836-Cross Infection,
pubmed-meshheading:17129836-Demography,
pubmed-meshheading:17129836-Drug Resistance, Multiple, Bacterial,
pubmed-meshheading:17129836-Drug Utilization,
pubmed-meshheading:17129836-Gram-Negative Bacterial Infections,
pubmed-meshheading:17129836-Humans,
pubmed-meshheading:17129836-Intensive Care Units,
pubmed-meshheading:17129836-Italy,
pubmed-meshheading:17129836-Length of Stay,
pubmed-meshheading:17129836-Microbial Sensitivity Tests,
pubmed-meshheading:17129836-Middle Aged,
pubmed-meshheading:17129836-Retrospective Studies
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| pubmed:year |
2006
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| pubmed:articleTitle |
Antimicrobial use and resistance among Gram-negative bacilli in an Italian intensive care unit (ICU).
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| pubmed:affiliation |
Department of Infectious Diseases, University of Genoa School of Medicine, San Martino Hospital, Genoa, Italy. matteo.bassetti@hsanmartino.it
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| pubmed:publicationType |
Journal Article
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