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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
1991-8-22
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pubmed:abstractText |
The effect of inhibition of brain histamine synthesis by alpha-fluoromethylhistidine (alpha-FMH) on the pituitary adrenocortical activity stimulated by D-Ala-D-Leu-enkephalinamide (DADL) and morphine was investigated indirectly through corticosterone secretion in conscious rats. alpha-FMH (20 mg/kg i.p.) drastically reduced the whole brain histamine content, measured 2 h later. The same pretreatment also considerably reduced the corticosterone response to morphine given intraperitoneally. When alpha-FMH was administered intracerebroventricularly (50 micrograms), the maximum inhibition of the corticosterone response to DADL and morphine occurred 4 h after administration, which may suggest a weaker accessibility of alpha-FMH from the cerebral ventricle to the brain structures involved in pituitary-adrenocortical stimulation. The corticosterone responses were not related to the core temperature changes. These results indicate that inhibition of brain histamine synthesis by alpha-FMH considerably impairs the pituitary-adrenocortical response to the opioid delta- and mu-receptor agonists DADL and morphine. They also suggest that neuronal histamine is significantly involved in the central stimulation of the pituitary-adrenal axis by opioids.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Corticosterone,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine,
http://linkedlifedata.com/resource/pubmed/chemical/Enkephalin, Leucine-2-Alanine,
http://linkedlifedata.com/resource/pubmed/chemical/Histidine Decarboxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Methylhistidines,
http://linkedlifedata.com/resource/pubmed/chemical/Morphine,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, delta,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Opioid, mu,
http://linkedlifedata.com/resource/pubmed/chemical/alpha-fluoromethylhistidine,
http://linkedlifedata.com/resource/pubmed/chemical/enkephalinamide-Leu,
http://linkedlifedata.com/resource/pubmed/chemical/enkephalinamide-Leu, Ala(2)-
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pubmed:status |
MEDLINE
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pubmed:issn |
0031-7012
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
188-96
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:1712972-Animals,
pubmed-meshheading:1712972-Body Temperature,
pubmed-meshheading:1712972-Brain,
pubmed-meshheading:1712972-Corticosterone,
pubmed-meshheading:1712972-Enkephalin, Leucine,
pubmed-meshheading:1712972-Enkephalin, Leucine-2-Alanine,
pubmed-meshheading:1712972-Histamine Release,
pubmed-meshheading:1712972-Histidine Decarboxylase,
pubmed-meshheading:1712972-Male,
pubmed-meshheading:1712972-Methylhistidines,
pubmed-meshheading:1712972-Morphine,
pubmed-meshheading:1712972-Pituitary-Adrenal System,
pubmed-meshheading:1712972-Rats,
pubmed-meshheading:1712972-Rats, Inbred Strains,
pubmed-meshheading:1712972-Receptors, Opioid,
pubmed-meshheading:1712972-Receptors, Opioid, delta,
pubmed-meshheading:1712972-Receptors, Opioid, mu
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pubmed:year |
1991
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pubmed:articleTitle |
Alpha-fluoromethylhistidine decreases the Leu-enkephalinamide- and morphine-induced corticosterone response in rats.
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pubmed:affiliation |
Institute of Pharmacology, Polish Academy of Sciences, Kraków.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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