17129726

Source:http://linkedlifedata.com/resource/pubmed/id/17129726

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0162758, umls-concept:C0243076, umls-concept:C0379900
pubmed:issue	4
pubmed:dateCreated	2007-2-5
pubmed:abstractText	Investigation of halogen substitution in lead compound 1 has led to the identification of analogues which combine high affinity for 5-HT(1A) receptors and potent serotonin reuptake inhibitory activity. Several compounds show an improved selectivity over 5-HT(1B) and 5-HT(1D) receptors and a superior pharmacokinetic profile in the rat.
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/9107377
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzoxazines, http://linkedlifedata.com/resource/pubmed/chemical/Indicators and Reagents, http://linkedlifedata.com/resource/pubmed/chemical/Piperazines, http://linkedlifedata.com/resource/pubmed/chemical/Pyridines, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1A, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1B, http://linkedlifedata.com/resource/pubmed/chemical/Receptor, Serotonin, 5-HT1D, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Antagonists, http://linkedlifedata.com/resource/pubmed/chemical/Serotonin Uptake Inhibitors, http://linkedlifedata.com/resource/pubmed/chemical/WAY 100635
pubmed:status	MEDLINE
pubmed:month	Feb
pubmed:issn	0960-894X
pubmed:author	pubmed-author:BlaneyFrank EFE, pubmed-author:GoodacreCaroline JCJ, pubmed-author:LovellPeter JPJ, pubmed-author:ScottClaire MCM, pubmed-author:SmithPaul WPW, pubmed-author:StarrKathryn RKR, pubmed-author:ThewlisKevin MKM, pubmed-author:VongAntonio K KAK, pubmed-author:WardSimon ESE, pubmed-author:WatsonJeannette MJM
pubmed:issnType	Print
pubmed:day	15
pubmed:volume	17
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	1033-6
pubmed:meshHeading	pubmed-meshheading:17129726-Animals, pubmed-meshheading:17129726-Benzoxazines, pubmed-meshheading:17129726-Binding, Competitive, pubmed-meshheading:17129726-CHO Cells, pubmed-meshheading:17129726-Callithrix, pubmed-meshheading:17129726-Cell Line, pubmed-meshheading:17129726-Cerebral Cortex, pubmed-meshheading:17129726-Cricetinae, pubmed-meshheading:17129726-Cricetulus, pubmed-meshheading:17129726-Guinea Pigs, pubmed-meshheading:17129726-Humans, pubmed-meshheading:17129726-Indicators and Reagents, pubmed-meshheading:17129726-Magnetic Resonance Spectroscopy, pubmed-meshheading:17129726-Mass Spectrometry, pubmed-meshheading:17129726-Models, Molecular, pubmed-meshheading:17129726-Piperazines, pubmed-meshheading:17129726-Pyridines, pubmed-meshheading:17129726-Radioligand Assay, pubmed-meshheading:17129726-Rats, pubmed-meshheading:17129726-Receptor, Serotonin, 5-HT1A, pubmed-meshheading:17129726-Receptor, Serotonin, 5-HT1B, pubmed-meshheading:17129726-Receptor, Serotonin, 5-HT1D, pubmed-meshheading:17129726-Serotonin Antagonists, pubmed-meshheading:17129726-Serotonin Uptake Inhibitors, pubmed-meshheading:17129726-Synaptosomes
pubmed:year	2007
pubmed:articleTitle	3,4-Dihydro-2H-benzoxazinones as dual-acting 5-HT1A receptor antagonists and serotonin reuptake inhibitors.
pubmed:affiliation	Psychiatry Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex CM19 5AW, UK. Peter.J.Lovell@gsk.com
pubmed:publicationType	Journal Article