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rdf:type |
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lifeskim:mentions |
umls-concept:C0166417,
umls-concept:C0205314,
umls-concept:C0220781,
umls-concept:C0243192,
umls-concept:C0439097,
umls-concept:C0456387,
umls-concept:C0679622,
umls-concept:C1547348,
umls-concept:C1554184,
umls-concept:C1705241,
umls-concept:C1707689,
umls-concept:C1883254
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pubmed:issue |
4
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pubmed:dateCreated |
2007-2-5
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pubmed:abstractText |
The design and synthesis of dual PPAR gamma/delta agonist (R)-3-{2-ethyl-4-[3-(4-ethyl-2-pyridin-2-yl-phenoxy)-butoxy]-phenyl}propionic acid is described. This compound dose-dependently lowered plasma glucose in hyperglycemic male Zucker diabetic fatty (ZDF) rats and produced less weight gain relative to rosiglitazone at an equivalent level of glucose control.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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|
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
pubmed-author:BroderickCarol LCL,
pubmed-author:EtgenGary JGJ,
pubmed-author:GonzalezIsabel CIC,
pubmed-author:IradierFatimaF,
pubmed-author:LamarJasonJ,
pubmed-author:MantloNathanN,
pubmed-author:Montrose-RafizadehChahrzadC,
pubmed-author:OldhamBrian ABA,
pubmed-author:WinneroskiLeonard LLL,
pubmed-author:XuYanpingY,
pubmed-author:YorkJeremyJ,
pubmed-author:YumibeNathanN,
pubmed-author:ZinkRichardR
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pubmed:issnType |
Print
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pubmed:day |
15
|
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pubmed:volume |
17
|
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1052-5
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17129725-Animals,
pubmed-meshheading:17129725-Blood Glucose,
pubmed-meshheading:17129725-Dose-Response Relationship, Drug,
pubmed-meshheading:17129725-Drug Design,
pubmed-meshheading:17129725-Female,
pubmed-meshheading:17129725-Half-Life,
pubmed-meshheading:17129725-Humans,
pubmed-meshheading:17129725-Hypoglycemic Agents,
pubmed-meshheading:17129725-Indicators and Reagents,
pubmed-meshheading:17129725-Insulin,
pubmed-meshheading:17129725-Male,
pubmed-meshheading:17129725-PPAR delta,
pubmed-meshheading:17129725-PPAR gamma,
pubmed-meshheading:17129725-Rats,
pubmed-meshheading:17129725-Rats, Sprague-Dawley,
pubmed-meshheading:17129725-Rats, Zucker,
pubmed-meshheading:17129725-Structure-Activity Relationship,
pubmed-meshheading:17129725-Thiazolidinediones,
pubmed-meshheading:17129725-Weight Gain
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pubmed:year |
2007
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pubmed:articleTitle |
Design and synthesis of a novel class of dual PPARgamma/delta agonists.
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pubmed:affiliation |
Lilly Research Laboratories, A Division of Eli Lilly & Company, Lilly Corporate center, Indianapolis, IN 46285, USA. gonzalez_isabel_c@lilly.com
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pubmed:publicationType |
Journal Article,
Comparative Study
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