17128289

Source:http://linkedlifedata.com/resource/pubmed/id/17128289

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Predicate	Object
rdf:type	pubmed:Citation
lifeskim:mentions	umls-concept:C0021467, umls-concept:C0021469, umls-concept:C0030163, umls-concept:C0257190, umls-concept:C0301630, umls-concept:C0439849, umls-concept:C0441655
pubmed:issue	1
pubmed:dateCreated	2007-1-10
pubmed:abstractText	Ivabradine, a specific and use-dependent I(f) inhibitor, exerts anti-ischaemic activity purely by reducing heart rate. The aim of this work was to characterize its effect on the predominant HCN channel isoform expressed in human sino-atrial nodes (hSAN), to determine its kinetics in HCN channels from multicellular preparations and rate-dependency of its action.
pubmed:commentsCorrections	http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-10212270, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-10228147, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-10400919, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-10575196, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-11133998, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-11248683, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-11821534, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-12084770, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-12514127, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-12591750, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-12928435, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-14575801, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-14576519, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-14695028, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-14695029, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-14720471, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-15774493, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-15837575, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-15914112, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-16214830, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-16407510, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-2432247, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-8032660, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-8222132, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-8799581, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-9450615, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-9630217, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-9634236, http://linkedlifedata.com/resource/pubmed/commentcorrection/17128289-9728900
pubmed:language	eng
pubmed:journal	http://linkedlifedata.com/resource/pubmed/journal/7502536
pubmed:citationSubset	IM
pubmed:chemical	http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines, http://linkedlifedata.com/resource/pubmed/chemical/Cyclic Nucleotide-Gated Cation..., http://linkedlifedata.com/resource/pubmed/chemical/HCN4 protein, human, http://linkedlifedata.com/resource/pubmed/chemical/Ion Channels, http://linkedlifedata.com/resource/pubmed/chemical/Muscle Proteins, http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger, http://linkedlifedata.com/resource/pubmed/chemical/ivabradine
pubmed:status	MEDLINE
pubmed:month	Jan
pubmed:issn	0007-1188
pubmed:author	pubmed-author:BedutSS, pubmed-author:BoutinJ-AJA, pubmed-author:Brunel-JacqueminCC, pubmed-author:ChomaratPP, pubmed-author:CogéFF, pubmed-author:GuillauminJ-PJP, pubmed-author:PeglionJ-LJL, pubmed-author:PiffardLL, pubmed-author:ThollonCC, pubmed-author:VilaineJ-PJP, pubmed-author:VilleneuveNN
pubmed:issnType	Print
pubmed:volume	150
pubmed:owner	NLM
pubmed:authorsComplete	Y
pubmed:pagination	37-46
pubmed:dateRevised	2009-11-18
pubmed:meshHeading	pubmed-meshheading:17128289-Action Potentials, pubmed-meshheading:17128289-Animals, pubmed-meshheading:17128289-Benzazepines, pubmed-meshheading:17128289-Biological Clocks, pubmed-meshheading:17128289-CHO Cells, pubmed-meshheading:17128289-Cricetinae, pubmed-meshheading:17128289-Cricetulus, pubmed-meshheading:17128289-Cyclic Nucleotide-Gated Cation Channels, pubmed-meshheading:17128289-Female, pubmed-meshheading:17128289-Heart Rate, pubmed-meshheading:17128289-Humans, pubmed-meshheading:17128289-Ion Channels, pubmed-meshheading:17128289-Male, pubmed-meshheading:17128289-Muscle Proteins, pubmed-meshheading:17128289-RNA, Messenger, pubmed-meshheading:17128289-Rabbits, pubmed-meshheading:17128289-Rats, pubmed-meshheading:17128289-Rats, Wistar, pubmed-meshheading:17128289-Reverse Transcriptase Polymerase Chain Reaction, pubmed-meshheading:17128289-Swine
pubmed:year	2007
pubmed:articleTitle	Use-dependent inhibition of hHCN4 by ivabradine and relationship with reduction in pacemaker activity.
pubmed:affiliation	Division Pathologies Cardiaques et Vasculaires, Institut de Recherches Servier, 11 rue des Moulineaux, Suresnes 92150, France. catherine.thollon@fr.netgrs.com
pubmed:publicationType	Journal Article