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pubmed:abstractText |
A series of 4,5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC(50) value as low as 0.022 and 0.065nM, respectively.
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pubmed:affiliation |
National Research Institute of Chinese Medicine, No. 155-1, Section 2, Li-Nung Street, Peitou, Taipei 112, Taiwan, ROC.
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