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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1-2
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pubmed:dateCreated |
2007-1-8
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pubmed:abstractText |
Rhesus monkeys immunized with MOG(34-56), a dominant T-cell epitope from myelin/oligodendrocyte glycoprotein, develop an acute neurological disease resembling acute disseminated encephalomyelitis (ADEM) in humans. The typical large demyelinated lesions and mononuclear infiltrates in the monkey brains are caused by MOG(34-56) T-cells. We show that MOG(34-56)-reactive CD4+ and CD8+ T-cells are induced in monkeys immunized with a peptide from the human CMV major capsid protein (UL86; 981-1003), that shares sequence similarity with MOG(34-56). Monkeys sensitized against the viral peptide and subsequently challenged with MOG(34-56) display histological signs of encephalitis, but do not show overt neurological signs.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies,
http://linkedlifedata.com/resource/pubmed/chemical/Capsid Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Epitopes, T-Lymphocyte,
http://linkedlifedata.com/resource/pubmed/chemical/Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Myelin-Associated Glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Fragments,
http://linkedlifedata.com/resource/pubmed/chemical/Polyethylene Glycols,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/major capsid protein...,
http://linkedlifedata.com/resource/pubmed/chemical/myelin oligodendrocyte glycoprotein,
http://linkedlifedata.com/resource/pubmed/chemical/polyoxyethanyl 600 cholesteryl...
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0165-5728
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pubmed:author |
pubmed-author:'t HartBert ABA,
pubmed-author:AmorSandraS,
pubmed-author:BajramovicJeffreyJ,
pubmed-author:BauerJanJ,
pubmed-author:Ben-NunAvrahamA,
pubmed-author:BovenLeonieL,
pubmed-author:BrokHerbert P MHP,
pubmed-author:Celebi-PaulLiesbethL,
pubmed-author:HintzenRogier QRQ,
pubmed-author:JagessarAnwarA,
pubmed-author:KapYolanda SYS,
pubmed-author:KeirGeoffG,
pubmed-author:Kerlero de RosboNicoleN,
pubmed-author:LamanJon DJD,
pubmed-author:van MeursMarjanM
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pubmed:issnType |
Print
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pubmed:volume |
182
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
135-52
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17126916-Animals,
pubmed-meshheading:17126916-Antibodies,
pubmed-meshheading:17126916-Brain,
pubmed-meshheading:17126916-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17126916-CD8-Positive T-Lymphocytes,
pubmed-meshheading:17126916-Capsid Proteins,
pubmed-meshheading:17126916-Cell Line,
pubmed-meshheading:17126916-Cell Proliferation,
pubmed-meshheading:17126916-Cholesterol,
pubmed-meshheading:17126916-Cross Reactions,
pubmed-meshheading:17126916-Encephalomyelitis, Autoimmune, Experimental,
pubmed-meshheading:17126916-Epitopes, T-Lymphocyte,
pubmed-meshheading:17126916-Female,
pubmed-meshheading:17126916-Glycoproteins,
pubmed-meshheading:17126916-Humans,
pubmed-meshheading:17126916-Lymphocyte Activation,
pubmed-meshheading:17126916-Macaca mulatta,
pubmed-meshheading:17126916-Male,
pubmed-meshheading:17126916-Monocytes,
pubmed-meshheading:17126916-Myelin Proteins,
pubmed-meshheading:17126916-Myelin-Associated Glycoprotein,
pubmed-meshheading:17126916-Peptide Fragments,
pubmed-meshheading:17126916-Polyethylene Glycols,
pubmed-meshheading:17126916-Recombinant Proteins,
pubmed-meshheading:17126916-Spinal Cord
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pubmed:year |
2007
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pubmed:articleTitle |
The human CMV-UL86 peptide 981-1003 shares a crossreactive T-cell epitope with the encephalitogenic MOG peptide 34-56, but lacks the capacity to induce EAE in rhesus monkeys.
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pubmed:affiliation |
Department of Immunobiology, Biomedical Primate Research Centre, 2288 GJ Rijswijk, The Netherlands.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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