Linked Life Data

1712658

Source:http://linkedlifedata.com/resource/pubmed/id/1712658

Statements in which the resource exists.
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pubmed-article:1712658pubmed:abstractTextIn the adult, pentobarbitone-anaesthetized rabbit, the in vivo release of substance P-like immunoreactivity was measured in the nucleus tractus solitarii using microdialysis and radioimmunoassay. Increased 160 +/- 16%) extracellular concentrations of substance P-like immunoreactivity were observed during hypoxic provocations of 9% O2 in N2 which also resulted in an increase in phrenic nerve activity. In bilateral carotid sinus nerve-denervated animals no enhanced release of substance P was seen in response to hypoxic challenges (105 +/- 6%) and the phrenic nerve activity was not significantly affected. Perfusion of the nucleus tractus solitarii region with the dopamine agonist, apomorphine (10(-5) M) resulted in a significant decrease in the extracellular level of substance P. These results provide further evidence that substance P is involved in the mediation of the hypoxic drive inputs from the peripheral chemoreceptors. The interactions of apomorphine with substance P release might also suggest a presynaptic modulation of substance Pergic neurons by dopamine in the nucleus tractus solitarii.lld:pubmed
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pubmed-article:1712658pubmed:articleTitleEnhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input.lld:pubmed
pubmed-article:1712658pubmed:affiliationNobel Institute for Neurophysiology, Karolinska Hospital, Stockholm, Sweden.lld:pubmed
pubmed-article:1712658pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:1712658pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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