Switch to
Predicate | Object |
---|---|
rdf:type | |
lifeskim:mentions |
umls-concept:C0030685,
umls-concept:C0034493,
umls-concept:C0035820,
umls-concept:C0038585,
umls-concept:C0175518,
umls-concept:C0205100,
umls-concept:C0242184,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1515655,
umls-concept:C1708517,
umls-concept:C1963578,
umls-concept:C2349975
|
pubmed:issue |
2
|
pubmed:dateCreated |
1991-8-22
|
pubmed:abstractText |
In the adult, pentobarbitone-anaesthetized rabbit, the in vivo release of substance P-like immunoreactivity was measured in the nucleus tractus solitarii using microdialysis and radioimmunoassay. Increased 160 +/- 16%) extracellular concentrations of substance P-like immunoreactivity were observed during hypoxic provocations of 9% O2 in N2 which also resulted in an increase in phrenic nerve activity. In bilateral carotid sinus nerve-denervated animals no enhanced release of substance P was seen in response to hypoxic challenges (105 +/- 6%) and the phrenic nerve activity was not significantly affected. Perfusion of the nucleus tractus solitarii region with the dopamine agonist, apomorphine (10(-5) M) resulted in a significant decrease in the extracellular level of substance P. These results provide further evidence that substance P is involved in the mediation of the hypoxic drive inputs from the peripheral chemoreceptors. The interactions of apomorphine with substance P release might also suggest a presynaptic modulation of substance Pergic neurons by dopamine in the nucleus tractus solitarii.
|
pubmed:grant | |
pubmed:language |
eng
|
pubmed:journal | |
pubmed:citationSubset |
IM
|
pubmed:chemical | |
pubmed:status |
MEDLINE
|
pubmed:month |
Apr
|
pubmed:issn |
0006-8993
|
pubmed:author | |
pubmed:issnType |
Print
|
pubmed:day |
19
|
pubmed:volume |
546
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
211-6
|
pubmed:dateRevised |
2008-11-21
|
pubmed:meshHeading |
pubmed-meshheading:1712658-Animals,
pubmed-meshheading:1712658-Anoxia,
pubmed-meshheading:1712658-Apomorphine,
pubmed-meshheading:1712658-Carotid Sinus,
pubmed-meshheading:1712658-Chemoreceptor Cells,
pubmed-meshheading:1712658-Dialysis,
pubmed-meshheading:1712658-Dopamine,
pubmed-meshheading:1712658-Medulla Oblongata,
pubmed-meshheading:1712658-Neurons, Afferent,
pubmed-meshheading:1712658-Peripheral Nerves,
pubmed-meshheading:1712658-Phrenic Nerve,
pubmed-meshheading:1712658-Rabbits,
pubmed-meshheading:1712658-Radioimmunoassay,
pubmed-meshheading:1712658-Substance P
|
pubmed:year |
1991
|
pubmed:articleTitle |
Enhanced in vivo release of substance P in the nucleus tractus solitarii during hypoxia in the rabbit: role of peripheral input.
|
pubmed:affiliation |
Nobel Institute for Neurophysiology, Karolinska Hospital, Stockholm, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
|