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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-12-15
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pubmed:abstractText |
Multiparallel amenable syntheses of 6-methoxy-8-amino-4-oxo-1,4-dihydroquinoline-2-carboxylic acid-(4-morpholin-4-yl-phenyl)amides (I) and 4-amino-6-methoxy-8-(4-methyl-piperazin-1-yl)-quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides (II) which facilitate late-stage diversification at the 8-position of (I) and at the 4- and 8-positions of (II) are described. The resulting novel series were determined to contain potent 5HT(1B) antagonists. Preliminary SAR data are presented.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
939-50
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pubmed:meshHeading |
pubmed-meshheading:17126021-Amides,
pubmed-meshheading:17126021-Chromatography, High Pressure Liquid,
pubmed-meshheading:17126021-Indicators and Reagents,
pubmed-meshheading:17126021-Morpholines,
pubmed-meshheading:17126021-Quinolones,
pubmed-meshheading:17126021-Receptor, Serotonin, 5-HT1B,
pubmed-meshheading:17126021-Serotonin Antagonists,
pubmed-meshheading:17126021-Structure-Activity Relationship
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis of novel quinolone and quinoline-2-carboxylic acid (4-morpholin-4-yl-phenyl)amides: a late-stage diversification approach to potent 5HT1B antagonists.
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pubmed:affiliation |
CNS Chemistry and Neuroscience, AstraZeneca Pharmaceuticals LP, 1800 Concord Pike, Wilmington, DE 19850, USA. carey.horchler@astrazeneca.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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