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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-12-15
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pubmed:abstractText |
Six novel ibuprofen derivatives and related structures, incorporating a proline moiety and designed for neurodegenerative disorders, are studied. They possess anti-inflammatory properties and three of them inhibited lipoxygenase. One compound was found to inhibit cyclooxygenase (COX)-2 production in spleenocytes from arthritic rats. The HS-containing compounds are potent antioxidants and one of them protected against glutathione loss after cerebral ischemia/reperfusion. They demonstrated lipid-lowering ability and seem to acquire low gastrointestinal toxicity. Acetylcholinesterase inhibitory activity, found in two of these compounds, may be an asset to their actions.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/2,2-diphenyl-1-picrylhydrazyl,
http://linkedlifedata.com/resource/pubmed/chemical/Antioxidants,
http://linkedlifedata.com/resource/pubmed/chemical/Biphenyl Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Cholesterol,
http://linkedlifedata.com/resource/pubmed/chemical/Cholinesterase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Cyclooxygenase 2 Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Freund's Adjuvant,
http://linkedlifedata.com/resource/pubmed/chemical/Glutathione,
http://linkedlifedata.com/resource/pubmed/chemical/Ibuprofen,
http://linkedlifedata.com/resource/pubmed/chemical/Lipoxygenase Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Neuroprotective Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Nootropic Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Picrates,
http://linkedlifedata.com/resource/pubmed/chemical/Triglycerides
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0968-0896
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
951-61
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:17126019-Animals,
pubmed-meshheading:17126019-Antioxidants,
pubmed-meshheading:17126019-Arthritis, Experimental,
pubmed-meshheading:17126019-Biphenyl Compounds,
pubmed-meshheading:17126019-Blood-Brain Barrier,
pubmed-meshheading:17126019-Cholesterol,
pubmed-meshheading:17126019-Cholinesterase Inhibitors,
pubmed-meshheading:17126019-Cyclooxygenase 2 Inhibitors,
pubmed-meshheading:17126019-Freund's Adjuvant,
pubmed-meshheading:17126019-Gastrointestinal Diseases,
pubmed-meshheading:17126019-Glutathione,
pubmed-meshheading:17126019-Hyperlipidemias,
pubmed-meshheading:17126019-Hypoxia-Ischemia, Brain,
pubmed-meshheading:17126019-Ibuprofen,
pubmed-meshheading:17126019-Lipid Peroxidation,
pubmed-meshheading:17126019-Lipoxygenase Inhibitors,
pubmed-meshheading:17126019-Mice,
pubmed-meshheading:17126019-Microsomes, Liver,
pubmed-meshheading:17126019-Neuroprotective Agents,
pubmed-meshheading:17126019-Nootropic Agents,
pubmed-meshheading:17126019-Oxidative Stress,
pubmed-meshheading:17126019-Picrates,
pubmed-meshheading:17126019-Rats,
pubmed-meshheading:17126019-Spleen,
pubmed-meshheading:17126019-Triglycerides
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pubmed:year |
2007
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pubmed:articleTitle |
Design and study of some novel ibuprofen derivatives with potential nootropic and neuroprotective properties.
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pubmed:affiliation |
Department of Pharmaceutical Chemistry, School of Pharmacy, Aristotelian University of Thessaloniki, Thessaloniki 54124, Greece.
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pubmed:publicationType |
Journal Article
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