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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
4
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pubmed:dateCreated |
2007-5-8
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pubmed:abstractText |
Type 1 diabetes mellitus (T1DM) is a T-cell-mediated autoimmune disease that leads to the destruction of insulin-producing beta cells. Treatment with DiaPep277, a peptide derived from heat-shock protein 60 (hsp60), has been found to slow the deterioration of beta-cell function after clinical onset of diabetes in NOD mice and human adults. Our aim was to evaluate the efficacy and safety of DiaPep277 treatment in attenuating beta-cell destruction in children with recent-onset T1DM.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
1520-7552
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2007 John Wiley & Sons, Ltd.
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
286-91
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:17124721-Adolescent,
pubmed-meshheading:17124721-C-Peptide,
pubmed-meshheading:17124721-Chaperonin 60,
pubmed-meshheading:17124721-Child,
pubmed-meshheading:17124721-Child, Preschool,
pubmed-meshheading:17124721-Diabetes Mellitus, Type 1,
pubmed-meshheading:17124721-Dose-Response Relationship, Drug,
pubmed-meshheading:17124721-Double-Blind Method,
pubmed-meshheading:17124721-Drug Therapy, Combination,
pubmed-meshheading:17124721-Female,
pubmed-meshheading:17124721-Follow-Up Studies,
pubmed-meshheading:17124721-Gastroenteritis,
pubmed-meshheading:17124721-Hemoglobin A, Glycosylated,
pubmed-meshheading:17124721-Humans,
pubmed-meshheading:17124721-Hypoglycemic Agents,
pubmed-meshheading:17124721-Injections, Subcutaneous,
pubmed-meshheading:17124721-Insulin,
pubmed-meshheading:17124721-Male,
pubmed-meshheading:17124721-Peptide Fragments,
pubmed-meshheading:17124721-Peptides,
pubmed-meshheading:17124721-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
Heat-shock protein peptide DiaPep277 treatment in children with newly diagnosed type 1 diabetes: a randomised, double-blind phase II study.
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pubmed:affiliation |
The institute for Endocrinology and Diabetes, National Center of Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Clinical Trial, Phase II
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