| pubmed-article:17123922 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C0042444 | lld:lifeskim |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C0017436 | lld:lifeskim |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C0011209 | lld:lifeskim |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C1450054 | lld:lifeskim |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C1553035 | lld:lifeskim |
| pubmed-article:17123922 | lifeskim:mentions | umls-concept:C0443252 | lld:lifeskim |
| pubmed-article:17123922 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:17123922 | pubmed:dateCreated | 2006-11-24 | lld:pubmed |
| pubmed-article:17123922 | pubmed:abstractText | Micro- and nanoparticles of poly(lactide-co-glycolide) (PLGA) loading gentamicin were prepared by a solvent evaporation method with the aim of obtaining appropriate vectors for systemic administration. Microspheres presented mean diameters below 3 microm and nanoparticles showed homogeneous sizes with a diameter of 320 nm. Drug loading was more efficient in the case of microencapsulation. The more hydrophilic copolymers with carboxyl-end groups yielded higher microparticle loadings, reaching encapsulation efficiencies up to 9.2 microg mg(-1) of polymer (502H, 503H or 75:25H). Nanoparticles made of 502H PLGA also achieved an acceptable level of encapsulation (6.2 microg mg(-1)). Particles prepared by using the solvent evaporation method showed no aggregation after hydration, in contrast to the microparticles prepared by spray-drying which showed fast and high auto-aggregation. In vitro release profiles revealed that 503H microspheres showed the highest burst during the first hour, while the most sustained release was for microparticles of 502H copolymer (40% of gentamicin remained in the formulation after 28 days). In summary, microspheres made of 502H, 503H and 75:25H and nanoparticles of 502H showed the best potential properties for systemic use in the treatment of intra-cellular gentamicin-susceptible pathogens. | lld:pubmed |
| pubmed-article:17123922 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17123922 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17123922 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17123922 | pubmed:month | Nov | lld:pubmed |
| pubmed-article:17123922 | pubmed:issn | 0265-2048 | lld:pubmed |
| pubmed-article:17123922 | pubmed:author | pubmed-author:GamazoCarlosC | lld:pubmed |
| pubmed-article:17123922 | pubmed:author | pubmed-author:Blanco-Prieto... | lld:pubmed |
| pubmed-article:17123922 | pubmed:author | pubmed-author:LecarozConcep... | lld:pubmed |
| pubmed-article:17123922 | pubmed:author | pubmed-author:RenedoMaría... | lld:pubmed |
| pubmed-article:17123922 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17123922 | pubmed:volume | 23 | lld:pubmed |
| pubmed-article:17123922 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17123922 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17123922 | pubmed:pagination | 782-92 | lld:pubmed |
| pubmed-article:17123922 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
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| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:meshHeading | pubmed-meshheading:17123922... | lld:pubmed |
| pubmed-article:17123922 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17123922 | pubmed:articleTitle | Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin. | lld:pubmed |
| pubmed-article:17123922 | pubmed:affiliation | Department of Microbiology, University of Navarra, Pamplona, Spain. | lld:pubmed |
| pubmed-article:17123922 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17123922 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17123922 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17123922 | lld:pubmed |
