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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7
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pubmed:dateCreated |
2006-11-24
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pubmed:abstractText |
Micro- and nanoparticles of poly(lactide-co-glycolide) (PLGA) loading gentamicin were prepared by a solvent evaporation method with the aim of obtaining appropriate vectors for systemic administration. Microspheres presented mean diameters below 3 microm and nanoparticles showed homogeneous sizes with a diameter of 320 nm. Drug loading was more efficient in the case of microencapsulation. The more hydrophilic copolymers with carboxyl-end groups yielded higher microparticle loadings, reaching encapsulation efficiencies up to 9.2 microg mg(-1) of polymer (502H, 503H or 75:25H). Nanoparticles made of 502H PLGA also achieved an acceptable level of encapsulation (6.2 microg mg(-1)). Particles prepared by using the solvent evaporation method showed no aggregation after hydration, in contrast to the microparticles prepared by spray-drying which showed fast and high auto-aggregation. In vitro release profiles revealed that 503H microspheres showed the highest burst during the first hour, while the most sustained release was for microparticles of 502H copolymer (40% of gentamicin remained in the formulation after 28 days). In summary, microspheres made of 502H, 503H and 75:25H and nanoparticles of 502H showed the best potential properties for systemic use in the treatment of intra-cellular gentamicin-susceptible pathogens.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0265-2048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
782-92
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17123922-Agglutination Tests,
pubmed-meshheading:17123922-Anti-Bacterial Agents,
pubmed-meshheading:17123922-Biocompatible Materials,
pubmed-meshheading:17123922-Calorimetry, Differential Scanning,
pubmed-meshheading:17123922-Delayed-Action Preparations,
pubmed-meshheading:17123922-Drug Compounding,
pubmed-meshheading:17123922-Gentamicins,
pubmed-meshheading:17123922-Lactic Acid,
pubmed-meshheading:17123922-Microscopy, Electron, Scanning,
pubmed-meshheading:17123922-Microspheres,
pubmed-meshheading:17123922-Nanoparticles,
pubmed-meshheading:17123922-Particle Size,
pubmed-meshheading:17123922-Pharmaceutical Vehicles,
pubmed-meshheading:17123922-Polyglycolic Acid,
pubmed-meshheading:17123922-Polymers,
pubmed-meshheading:17123922-Surface Properties,
pubmed-meshheading:17123922-X-Ray Diffraction
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pubmed:year |
2006
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pubmed:articleTitle |
Biodegradable micro- and nanoparticles as long-term delivery vehicles for gentamicin.
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pubmed:affiliation |
Department of Microbiology, University of Navarra, Pamplona, Spain.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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