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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
2007-1-22
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pubmed:abstractText |
Amidoxime and O-substituted derivatives of the bis-alkylamidine 1,12-bis(N,N'-acetamidinyl)dodecane were synthesized and evaluated as in vitro and in vivo antimalarial prodrugs. The bis-O-methylsulfonylamidoxime 8 and the bis-oxadiazolone 9 derivatives show relatively potent antimalarial activity after oral administration.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0960-894X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
17
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
593-6
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pubmed:meshHeading |
pubmed-meshheading:17123818-Administration, Oral,
pubmed-meshheading:17123818-Alkanes,
pubmed-meshheading:17123818-Amidines,
pubmed-meshheading:17123818-Animals,
pubmed-meshheading:17123818-Antimalarials,
pubmed-meshheading:17123818-Female,
pubmed-meshheading:17123818-Humans,
pubmed-meshheading:17123818-Hydroxylation,
pubmed-meshheading:17123818-Indicators and Reagents,
pubmed-meshheading:17123818-Injections, Intraperitoneal,
pubmed-meshheading:17123818-Malaria,
pubmed-meshheading:17123818-Malaria, Falciparum,
pubmed-meshheading:17123818-Mice,
pubmed-meshheading:17123818-Plasmodium cynomolgi,
pubmed-meshheading:17123818-Plasmodium falciparum
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pubmed:year |
2007
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pubmed:articleTitle |
Synthesis and antimalarial activity of new 1,12-bis(N,N'-acetamidinyl)dodecane derivatives.
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pubmed:affiliation |
Dynamique Moléculaire des Interactions Membranaires, UMR 5539, CNRS-Université de Montpellier II, 34095 Montpellier, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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