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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
|
| pubmed:dateCreated |
1991-8-12
|
| pubmed:abstractText |
To assess possible role of testing for IgM-specific antibody in the diagnosis and monitoring of patients with hepatitis C, we tested sera from 14 patients with acute and 97 patients with chronic non-A, non-B hepatitis for IgG and IgM antibody to hepatitis C virus. IgG antibody to hepatitis C virus was detected in 93% of acute cases and 91% of chronic cases. Of the 101 patients with IgG antibody to hepatitis C virus, 57% had IgM antibody to hepatitis C virus. None of the 20 healthy subjects or 40 patients with acute or chronic hepatitis A or hepatitis B had IgM antibody to hepatitis C virus. At the onset of clinical symptoms in acute hepatitis C, IgG antibody to hepatitis C virus was detected in 8 (57%) and IgM antibody to hepatitis C virus in 9 of 14 patients (64%). Eventually, both IgG and IgM antibody to hepatitis C virus became detectable in 13 of 14 patients with acute hepatitis C. Seven patients with antibody to hepatitis C virus resolved the acute infection within 6 mo and all seven cleared IgM antibody to hepatitis C virus, whereas two cleared IgG antibody to hepatitis C virus. Six patients had a chronic outcome of the acute infection and IgM antibody to hepatitis C virus persisted in detectable amounts for more than 6 mo in all (mean = 15.5 mo). Among 88 patients with chronic non-A, non-B hepatitis with IgG antibody to hepatitis C virus, IgM antibody to hepatitis C virus was detected in 45 (51%).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jul
|
| pubmed:issn |
0270-9139
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
14
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
38-43
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:1712340-Acute Disease,
pubmed-meshheading:1712340-Adult,
pubmed-meshheading:1712340-Aged,
pubmed-meshheading:1712340-Chronic Disease,
pubmed-meshheading:1712340-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:1712340-Female,
pubmed-meshheading:1712340-Follow-Up Studies,
pubmed-meshheading:1712340-Hepacivirus,
pubmed-meshheading:1712340-Hepatitis Antibodies,
pubmed-meshheading:1712340-Hepatitis C,
pubmed-meshheading:1712340-Hepatitis C Antibodies,
pubmed-meshheading:1712340-Humans,
pubmed-meshheading:1712340-Immunoglobulin M,
pubmed-meshheading:1712340-Male,
pubmed-meshheading:1712340-Middle Aged
|
| pubmed:year |
1991
|
| pubmed:articleTitle |
IgM antibody to hepatitis C virus in acute and chronic hepatitis C.
|
| pubmed:affiliation |
Department of Gastroenterology, Fundación Jiménez Díaz, Madrid, Spain.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|