| pubmed-article:17121182 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0262950 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0014442 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0024880 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0003693 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0003695 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0387583 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:17121182 | lifeskim:mentions | umls-concept:C0066248 | lld:lifeskim |
| pubmed-article:17121182 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:17121182 | pubmed:dateCreated | 2006-11-22 | lld:pubmed |
| pubmed-article:17121182 | pubmed:abstractText | Methyl gallate (MG) is a medicinal herbal product that is isolated from Paeonia lactiflora that inhibits cyclooxygenase-2 (COX-2) dependent phases of prostaglandin D2 (PGD2) generation in bone marrow-derived mast cells (BMMC) in a concentration-dependent manner with an IC50 values of 17.0 microM. This compound also found inhibited the COX-2-dependent conversion of the exogenous arachidonic acid to PGD2 in a dose-dependent manner with an IC50 values of 19.0 microM, using a COX enzyme assay kit. However, at concentrations up to 80 microM, MG did not inhibit COX-2 protein expression in BMMC, indicating that MG inhibits COX-2 activity directly. Furthermore, MG consistently inhibited the production of leukotriene C4 (LTC4) in a dose dependent manner, with an IC50 value of 5.3 microM. These results demonstrate that MG has a dual cyclooxygenase-2/5-lipoxygenase inhibitory activity, which might provide the basis for novel anti-inflammatory drugs. | lld:pubmed |
| pubmed-article:17121182 | pubmed:language | eng | lld:pubmed |
| pubmed-article:17121182 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:17121182 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:17121182 | pubmed:month | Oct | lld:pubmed |
| pubmed-article:17121182 | pubmed:issn | 0253-6269 | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:LeeEunkyungE | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:SonKun HoKH | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:ChangHyeun... | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:KimSe JongSJ | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:KimKil-UngKU | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:MoonTae... | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:JinMeihuaM | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:QuanZhejiuZ | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:YangJu HyeJH | lld:pubmed |
| pubmed-article:17121182 | pubmed:author | pubmed-author:SonJong KunJK | lld:pubmed |
| pubmed-article:17121182 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:17121182 | pubmed:volume | 29 | lld:pubmed |
| pubmed-article:17121182 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:17121182 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:17121182 | pubmed:pagination | 874-8 | lld:pubmed |
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| pubmed-article:17121182 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:17121182 | pubmed:articleTitle | Effects of methyl gallate on arachidonic acid metabolizing enzymes: Cyclooxygenase-2 and 5-lipoxygenase in mouse bone marrow-derived mast cells. | lld:pubmed |
| pubmed-article:17121182 | pubmed:affiliation | Research Institute of Natural Product Kyongbuk Provincial A T A, Uisung 769-803, Korea. | lld:pubmed |
| pubmed-article:17121182 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:17121182 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:17121182 | lld:pubmed |
