Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1991-8-2
pubmed:abstractText
We have identified a major T-cell epitope, amino acids 48-54 (DRAHYNI, in one-letter code) in the E7 open reading frame protein of human papillomavirus (HPV) type 16. Lymph node cells from mice immunized with synthetic peptides containing DRAHYNI proliferated and produced interleukin when challenged in vitro with peptide or whole HPV-16 E7 fusion protein. The T epitope was recognized in association with all five major histocompatibility complex class II I-A and I-E alleles tested. Synthetic peptides consisting of DRAHYNI linked to major B-cell epitopes on the E7 molecule formed immunogens capable of eliciting strong antibody responses to HPV-16 E7. The T epitope could provide help for the production of antibody to several B epitopes simultaneously, including a B epitope of HPV-18 E7 protein. Mice immunized with a peptide containing DRAHYNI and B epitope and, at a later date, infected with recombinant vaccinia E7 virus, displayed secondary antibody responses to E7. Because E7 has a role in cell transformation and is the most abundant viral protein in HPV-associated neoplastic cervical epithelial cells, the data have implications for vaccine strategies.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-1693666, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-1698872, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-1724617, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2410914, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2413457, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2420472, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2434994, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2438696, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2449694, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2450157, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2452085, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2460337, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2460636, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2470920, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2474830, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2478625, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2478626, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2478631, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2542020, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2553991, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2580713, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2783706, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2838573, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-2961803, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-3003388, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-3034571, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-3038534, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-4975324, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-6322903, http://linkedlifedata.com/resource/pubmed/commentcorrection/1712110-6982419
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
88
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
5887-91
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
1991
pubmed:articleTitle
A "public" T-helper epitope of the E7 transforming protein of human papillomavirus 16 provides cognate help for several E7 B-cell epitopes from cervical cancer-associated human papillomavirus genotypes.
pubmed:affiliation
Lions Human Immunology Laboratories, University of Queensland, Princess Alexandra Hospital, Brisbane, Australia.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't