Source:http://linkedlifedata.com/resource/pubmed/id/17120029
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-8-6
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pubmed:abstractText |
Mediastinal lymphangiomatosis in a 70-year-old woman was diagnosed on a medical checkup. The tumor was resistant to sclerotherapy with OK432 or bleomycin. The patient continued on a downhill course and died approximately 3 years after the initial diagnosis. Autopsy revealed a large tumor mass occupying the anterior mediastinum and firmly adhered to the pericardium and the pleura. The tumor consisted of two intermingled lesions: dilated vessels lined with D2-40-positive lymphatic endothelium and CD5-positive atypical cell nests with focal keratinization. The former was diagnosed as lymphangiomatosis and the latter as thymic squamous cell carcinoma. Vascular endothelial growth factor (VEGF)-C, a growth factor for lymphatic endothelial cells, was expressed by the carcinoma, and VEGF-C receptor was expressed by the endothelium of lymphangiomatosis. These findings suggested that VEGF-C derived from the thymic carcinoma induced the lymphangiomatosis lesion in a paracrine manner.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0945-6317
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
450
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
211-4
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pubmed:meshHeading |
pubmed-meshheading:17120029-Aged,
pubmed-meshheading:17120029-Female,
pubmed-meshheading:17120029-Humans,
pubmed-meshheading:17120029-Lymphangioma,
pubmed-meshheading:17120029-Mediastinal Neoplasms,
pubmed-meshheading:17120029-Neoplasms, Multiple Primary,
pubmed-meshheading:17120029-Thymus Neoplasms,
pubmed-meshheading:17120029-Vascular Endothelial Growth Factor C
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pubmed:year |
2007
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pubmed:articleTitle |
Mediastinal lymphangiomatosis coexisting with occult thymic carcinoma.
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pubmed:affiliation |
Department of Pathology, Graduate School of Medicine, Osaka University, Yamada-oka 2-2, Suita 565-0871, Japan.
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pubmed:publicationType |
Journal Article,
Case Reports,
Research Support, Non-U.S. Gov't
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