Source:http://linkedlifedata.com/resource/pubmed/id/17119535
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
2
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pubmed:dateCreated |
2007-1-18
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pubmed:abstractText |
We report the first genome-wide linkage analysis for reading and spelling in a sample of 403 families of twins, aged between 12 and 25 years taken from the normal population and unselected for reading ability. These traits showed heritabilities of 0.52-0.73, and support for linkage exceeded replication levels (lod > 1.44) of seven of the 11 linkages reported in dyslexic samples, namely: 2q22.3, 3p12-q13, 6q11.2, 7q32, 15q21.1, 18p21, and Xq27.3. For five of these (2q22.3, 6q11.2, 7q32, 18p21, and Xq27), this study provides the first independent replication. 1p34-36 and 2p15-16 received some support, with lods of 1.2 and 0.83, respectively, whereas two regions received little support (6p23-21.3 and 11p15.5). This study also identified two novel linkages at 4p15.33-16.1 and 17p13.3, which received suggestive support (max. lod 2.08 and 1.99, respectively).
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pubmed:grant | |
pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1018-4813
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
194-203
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17119535-Chromosome Mapping,
pubmed-meshheading:17119535-Chromosomes, Human, Pair 17,
pubmed-meshheading:17119535-Chromosomes, Human, Pair 4,
pubmed-meshheading:17119535-DNA Replication,
pubmed-meshheading:17119535-Dyslexia,
pubmed-meshheading:17119535-Genetic Linkage,
pubmed-meshheading:17119535-Genome, Human,
pubmed-meshheading:17119535-Humans,
pubmed-meshheading:17119535-Reading,
pubmed-meshheading:17119535-Siblings
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pubmed:year |
2007
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pubmed:articleTitle |
Replication of reported linkages for dyslexia and spelling and suggestive evidence for novel regions on chromosomes 4 and 17.
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pubmed:affiliation |
Department of Psychology, University of Edinburgh, Edinburgh, UK. tim.bates@ed.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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