Linked Life Data

17119465

Source:http://linkedlifedata.com/resource/pubmed/id/17119465

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-11-22
pubmed:abstractText
Reactive Oxygen Species (ROS), namely hydroxyl (*OH) and superoxide (O2*-) free radicals and hydrogen peroxide (H2O2), are involved in all oxidative stress phenomena. These latter occur in numerous pathological disorders such as, for example, cardiovascular diseases, diabetes or neurodegenerative diseases. Knowledge of thermodynamic (reduction potentials) and kinetic (rate constants) properties of ROS allows to draw up a rigorous overview of the chemical reactivity of these species. Hydroxyl free radicals (*OH) are powerful oxidants (very toxic species) which attack all the biomolecular targets (DNA, proteins, lipids...), giving other free radicals localized on the targets. Superoxide free radicals (O2*-) have a more graduated reactivity, since they don't directly react with biological molecules. However, some toxicity would be attributed to them via secondary radicular reactions. Other free radicals (of peroxyl RO2* and alkoxyl RO* types), belonging also to the ROS family, contribute by enhancement to oxidative stress.
pubmed:language
fre
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0003-4509
pubmed:author
pubmed:issnType
Print
pubmed:volume
64
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
365-72
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
[Physico-chemical aspects of reactive oxygen species].
pubmed:affiliation
Laboratoire de Chimie-Physique, UMR 8601 Cnrs-Université Paris 5, UFR Biomédicale des Saint-Pères, 45, rue des Saint-Pères, F 75270 Paris Cedex 06, USA.
pubmed:publicationType
Journal Article, English Abstract, Review