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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-11-22
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pubmed:abstractText |
Helicobacter pylori infection potently induces methylation of CpG islands in gastric mucosae, which is considered to decrease to a certain level after active H. pylori infection discontinues. Noncancerous gastric mucosae of H. pylori-negative cases with a gastric cancer had higher methylation levels than those of H. pylori-negative healthy individuals. Here, using cases with multiple gastric cancers, we analyzed whether the higher methylation levels correlated with the higher risk of gastric cancers.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
1055-9965
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
15
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2317-21
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:17119066-Aged,
pubmed-meshheading:17119066-CpG Islands,
pubmed-meshheading:17119066-DNA Methylation,
pubmed-meshheading:17119066-Female,
pubmed-meshheading:17119066-Gastric Mucosa,
pubmed-meshheading:17119066-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17119066-Genetic Variation,
pubmed-meshheading:17119066-Genotype,
pubmed-meshheading:17119066-Helicobacter pylori,
pubmed-meshheading:17119066-Humans,
pubmed-meshheading:17119066-Male,
pubmed-meshheading:17119066-Middle Aged,
pubmed-meshheading:17119066-Polymorphism, Genetic,
pubmed-meshheading:17119066-Risk,
pubmed-meshheading:17119066-Stomach Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
Higher methylation levels in gastric mucosae significantly correlate with higher risk of gastric cancers.
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pubmed:affiliation |
Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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