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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
5
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pubmed:dateCreated |
1991-7-31
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pubmed:abstractText |
A new hexapeptide analog of Substance P, containing a C-terminal thioamide group in the molecule [( Glp6, Mett11]SP6-11) was synthesized: Glp-Phe-Phe-Gly-Leu-Mett-NH2. Conversion to thioamide was accomplished from tert-butoxycarbonyl-L-methionine amide (Boc-Met-NH2) using Lawesson's Reagent. Its contracting activity on isolated guinea-pig ileum was considerably lower than that of [Glp6]SP6-11.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:issn |
0301-0244
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
42
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
483-90
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1711685-Animals,
pubmed-meshheading:1711685-Chemical Phenomena,
pubmed-meshheading:1711685-Chemistry,
pubmed-meshheading:1711685-Guinea Pigs,
pubmed-meshheading:1711685-Muscle, Smooth,
pubmed-meshheading:1711685-Muscle Contraction,
pubmed-meshheading:1711685-Peptide Fragments,
pubmed-meshheading:1711685-Pyrrolidonecarboxylic Acid,
pubmed-meshheading:1711685-Substance P,
pubmed-meshheading:1711685-Thioamides
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pubmed:articleTitle |
Synthesis and some biological properties of the hexapeptide analog of substance P with a C-terminal thioamide group.
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pubmed:affiliation |
Institute of Chemistry, University of Gda?sk, Poland.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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