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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-5-3
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pubmed:abstractText |
Edaravone (MCI-186) is a novel synthetic free radical scavenger intended to have neuroprotective effect against ischemic insult. It is currently used on patients with cerebral infarction. Here, we note beneficial pharmaceutical effects of edaravone in rat experimental traumatic brain injury. Under specific experimental conditions, edaravone minimized traumatic brain injury by functioning as a synthetic antioxidant. Clinical trials testing the efficacy of edaravone are warranted.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1523-0864
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
9
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
281-7
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pubmed:meshHeading |
pubmed-meshheading:17115943-Animals,
pubmed-meshheading:17115943-Antioxidants,
pubmed-meshheading:17115943-Antipyrine,
pubmed-meshheading:17115943-Blood,
pubmed-meshheading:17115943-Brain Injuries,
pubmed-meshheading:17115943-Free Radical Scavengers,
pubmed-meshheading:17115943-Humans,
pubmed-meshheading:17115943-Lipid Peroxidation,
pubmed-meshheading:17115943-Neurons,
pubmed-meshheading:17115943-Neuroprotective Agents,
pubmed-meshheading:17115943-Nitric Oxide,
pubmed-meshheading:17115943-Rats,
pubmed-meshheading:17115943-Reactive Oxygen Species,
pubmed-meshheading:17115943-Time Factors,
pubmed-meshheading:17115943-alpha-Tocopherol
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pubmed:year |
2007
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pubmed:articleTitle |
Does edaravone (MCI- 186) act as an antioxidant and a neuroprotector in experimental traumatic brain injury?
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pubmed:affiliation |
Showa University, Department of Emergency and Critical Care Medicine, Tokyo, Japan. kdop@med.showa-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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