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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2007-1-8
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pubmed:abstractText |
Tamoxifen is biotransformed to the potent anti-estrogen, endoxifen, by the cytochrome P450 (CYP) 2D6 enzyme. CYP2D6 genetic variation and inhibitors of the enzyme markedly reduce endoxifen plasma concentrations in tamoxifen-treated patients. Using a North Central Cancer Treatment Group adjuvant tamoxifen trial, we performed a comprehensive evaluation of CYP2D6 metabolism by assessing the combined effect of genetic variation and inhibition of the enzyme system on breast cancer recurrence and death.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0167-6806
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pubmed:author |
pubmed-author:AmesMatthew MMM,
pubmed-author:CouchFergus JFJ,
pubmed-author:DestaZeruesenayZ,
pubmed-author:FlockhartDavid ADA,
pubmed-author:FritcherEmily G BarrEG,
pubmed-author:GoetzMatthew PMP,
pubmed-author:IngleJames NJN,
pubmed-author:KnoxStacey KSK,
pubmed-author:LingleWilma LWL,
pubmed-author:NguyenAnneA,
pubmed-author:NibbeAndrea MAM,
pubmed-author:PerezEdith AEA,
pubmed-author:RaeJames MJM,
pubmed-author:ReynoldsCarolC,
pubmed-author:SafgrenStephanie LSL,
pubmed-author:SumanVera JVJ,
pubmed-author:VisscherDaniel WDW,
pubmed-author:WeinshilboumRichard MRM
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
113-21
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17115111-Adult,
pubmed-meshheading:17115111-Aged,
pubmed-meshheading:17115111-Aged, 80 and over,
pubmed-meshheading:17115111-Antineoplastic Agents, Hormonal,
pubmed-meshheading:17115111-Breast Neoplasms,
pubmed-meshheading:17115111-Chemotherapy, Adjuvant,
pubmed-meshheading:17115111-Cytochrome P-450 CYP2D6,
pubmed-meshheading:17115111-Female,
pubmed-meshheading:17115111-Genotype,
pubmed-meshheading:17115111-Humans,
pubmed-meshheading:17115111-Kaplan-Meier Estimate,
pubmed-meshheading:17115111-Middle Aged,
pubmed-meshheading:17115111-Neoplasm Recurrence, Local,
pubmed-meshheading:17115111-Proportional Hazards Models,
pubmed-meshheading:17115111-Tamoxifen,
pubmed-meshheading:17115111-Treatment Outcome
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pubmed:year |
2007
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pubmed:articleTitle |
The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen.
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pubmed:affiliation |
Department of Oncology, Mayo Clinic College of Medicine, 200 First Street Southwest, Rochester, MN , 55905, USA, goetz.matthew@mayo.edu.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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