rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
11
|
pubmed:dateCreated |
2006-11-20
|
pubmed:abstractText |
The function of Ag-specific central (T(CM)) and effector (T(EM)) memory CD4+ T lymphocytes remains poorly characterized in vivo in humans. Using CD154 as a marker of Ag-specific CD4+T cells, we studied the differentiation of memory subsets following anti-hepatitis B immunization. Hepatitis B surface Ag (HBs)-specific memory CD4+T cells were heterogeneous and included T(CM) (CCR7+CD27+) and T(EM) (CCR7(-)CD27(+/-)). HBs-specific T(CM) and T(EM) shared the capacity to produce multiple cytokines, including IL-2 and IFN-gamma. Several years postimmunization, approximately 10% of HBs-specific memory CD4+ T cells were in cycle (Ki67+) and the proliferating cells were CCR7+. These results suggest that the model of functional specialization of T(CM) and T(EM) cannot be applied to protein vaccine Ags and support the concept that T(CM) are capable of self-renewal and contribute to maintain the pool of memory cells.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
AIM
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/CCR7 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/CD40 Ligand,
http://linkedlifedata.com/resource/pubmed/chemical/Cytokines,
http://linkedlifedata.com/resource/pubmed/chemical/Engerix-B,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Surface Antigens,
http://linkedlifedata.com/resource/pubmed/chemical/Hepatitis B Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, CCR7,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Chemokine
|
pubmed:status |
MEDLINE
|
pubmed:month |
Dec
|
pubmed:issn |
0022-1767
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
1
|
pubmed:volume |
177
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
8185-90
|
pubmed:dateRevised |
2007-11-15
|
pubmed:meshHeading |
pubmed-meshheading:17114495-Adult,
pubmed-meshheading:17114495-CD4-Positive T-Lymphocytes,
pubmed-meshheading:17114495-CD40 Ligand,
pubmed-meshheading:17114495-Cell Differentiation,
pubmed-meshheading:17114495-Cell Proliferation,
pubmed-meshheading:17114495-Cytokines,
pubmed-meshheading:17114495-Flow Cytometry,
pubmed-meshheading:17114495-Hepatitis B Surface Antigens,
pubmed-meshheading:17114495-Hepatitis B Vaccines,
pubmed-meshheading:17114495-Humans,
pubmed-meshheading:17114495-Immunologic Memory,
pubmed-meshheading:17114495-Receptors, CCR7,
pubmed-meshheading:17114495-Receptors, Chemokine,
pubmed-meshheading:17114495-T-Lymphocyte Subsets
|
pubmed:year |
2006
|
pubmed:articleTitle |
Antigen-specific central memory CD4+ T lymphocytes produce multiple cytokines and proliferate in vivo in humans.
|
pubmed:affiliation |
Institute for Medical Immunology, Université Libre de Bruxelles, Rue Adrienne Bolland 8, 6041 Charleroi, Belgium.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|