|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
28-29
|
|
pubmed:dateCreated |
2006-12-4
|
|
pubmed:abstractText |
Mitochondrial thioredoxin (mtTrx) can be oxidized in response to inducers of oxidative stress; yet the functional consequences of the oxidation have not been determined. This study evaluated the redox status of mtTrx and its association to oxidant-induced apoptosis. Results showed that mtTrx was oxidized after exposure to peroxides and diamide. Overexpression of mtTrx protected against diamide-induced oxidation and cytotoxicity. Oxidation of mtTrx was also achieved by knocking down its reductase; and lead to increased susceptibility to cell death. The data indicate that the redox status of mtTrx is a regulatory mechanism underlying the vulnerability of mitochondria to oxidative injury.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-10215850,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11035250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11179387,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11525872,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11707400,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11795590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11879627,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-11898427,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-12032145,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-12039859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-12149099,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-12534348,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-12958160,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-16337887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-16797630,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-6617859,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-9006939,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-9714734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113580-9988709
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Dec
|
|
pubmed:issn |
0014-5793
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
11
|
|
pubmed:volume |
580
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
6596-602
|
|
pubmed:dateRevised |
2011-8-3
|
|
pubmed:meshHeading |
pubmed-meshheading:17113580-Cell Death,
pubmed-meshheading:17113580-Diamide,
pubmed-meshheading:17113580-Gene Expression,
pubmed-meshheading:17113580-Humans,
pubmed-meshheading:17113580-Membrane Potentials,
pubmed-meshheading:17113580-Mitochondria,
pubmed-meshheading:17113580-Mitochondrial Membranes,
pubmed-meshheading:17113580-Oxidants,
pubmed-meshheading:17113580-Oxidation-Reduction,
pubmed-meshheading:17113580-Oxidative Stress,
pubmed-meshheading:17113580-Peroxides,
pubmed-meshheading:17113580-Thioredoxin Reductase 2,
pubmed-meshheading:17113580-Thioredoxin-Disulfide Reductase,
pubmed-meshheading:17113580-Thioredoxins,
pubmed-meshheading:17113580-Time Factors,
pubmed-meshheading:17113580-tert-Butylhydroperoxide
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Mitochondrial thioredoxin in regulation of oxidant-induced cell death.
|
|
pubmed:affiliation |
Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
