|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
3
|
|
pubmed:dateCreated |
2007-1-22
|
|
pubmed:abstractText |
O-Carbamoylserine and O-carbamoylthreonine are glutamine analogues that were incorporated into a Stat3 inhibitory peptide to probe the requirements of Gln at the pY+3 position. Fmoc-Ser-NHBn and Fmoc-Thr-NHBn were converted to nitrophenyl carbonates and were attached to Rink resin via a side-chain carbamate linkage. After assembly of the peptide, acid treatment resulted in O-carbamoylserine and O-carbamoylthreonine-containing peptides. The order of affinity for Stat3 was Gln > Ser(CONH2) >> Thr(CONH2) suggesting a relatively tight binding pocket for the side chain of glutamine.
|
|
pubmed:grant |
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-10851046,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-11948098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-11994401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-12360277,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-12591923,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-14184938,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-16220982,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-6027514,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-7689747,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-7718743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-7871433,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17113289-8662591
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Feb
|
|
pubmed:issn |
0960-894X
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
1
|
|
pubmed:volume |
17
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
654-6
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Solid-phase synthesis of Stat3 inhibitors incorporating O-carbamoylserine and O-carbamoylthreonine as glutamine mimics.
|
|
pubmed:affiliation |
The University of Texas, MD Anderson Cancer Center, Department of Experimental Therapeutics, 1515 Holcombe Boulevard, Houston, TX 77030, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
|
