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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
6
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pubmed:dateCreated |
2007-5-7
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pubmed:abstractText |
Bisphenol A (BPA), known as an environmental endocrine disrupter, is widely used in industry and dentistry. We investigated the effects of fetal and neonatal exposure to bisphenol A (BPA) on the brain development of mice. The density of tyrosine hydroxylase (TH)-immunoreactive (IR) neurons in substantia nigra was significantly decreased in BPA-exposed female mice (3 microg/g powder food), but not in the male mice, as compared with that of the control mice. The densities of calbindin D-28 K-, calretinin- and parvalbumin-IR neurons in the cerebral cortex were not different between BPA-exposed and the control mice. The present study indicates that chronic exposure of BPA during prenatal and neonatal periods causes a decrease of TH-positive neurons in substantia nigra only in female mice brain.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0387-7604
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
29
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
352-6
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17113258-Air Pollutants, Occupational,
pubmed-meshheading:17113258-Animals,
pubmed-meshheading:17113258-Animals, Newborn,
pubmed-meshheading:17113258-Brain,
pubmed-meshheading:17113258-Dose-Response Relationship, Drug,
pubmed-meshheading:17113258-Embryo, Mammalian,
pubmed-meshheading:17113258-Female,
pubmed-meshheading:17113258-Gene Expression Regulation, Developmental,
pubmed-meshheading:17113258-Male,
pubmed-meshheading:17113258-Mice,
pubmed-meshheading:17113258-Nerve Tissue Proteins,
pubmed-meshheading:17113258-Phenols,
pubmed-meshheading:17113258-Pregnancy,
pubmed-meshheading:17113258-Prenatal Exposure Delayed Effects,
pubmed-meshheading:17113258-Sex Factors,
pubmed-meshheading:17113258-Tyrosine 3-Monooxygenase
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pubmed:year |
2007
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pubmed:articleTitle |
Effects of pre- and neonatal exposure to bisphenol A on murine brain development.
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pubmed:affiliation |
Department of Pathology and Applied Neurobiology, Kyoto Prefectural University of Medicine Graduate School of Medical Science, Kawaramachi Hirokoji, Kamigyo-ku, Kyoto 602-8566, Japan.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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