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pubmed-article:17112845pubmed:abstractTextSingle nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene correlate with the intestinal function of P-glycoprotein (PGP). PGP serves as a hydrophobic export pump that extrudes cyclosporine (CsA) across the luminal membrane thus preventing CsA absorption. These genetic variants may predict CsA exposure levels in the early posttransplantation period.lld:pubmed
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pubmed-article:17112845pubmed:articleTitleMDR1 C3435T polymorphisms correlate with cyclosporine levels in de novo renal recipients.lld:pubmed
pubmed-article:17112845pubmed:affiliationDepartment of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.lld:pubmed
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