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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
9
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pubmed:dateCreated |
2006-11-20
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pubmed:abstractText |
Single nucleotide polymorphisms (SNPs) in the multidrug resistance (MDR1) gene correlate with the intestinal function of P-glycoprotein (PGP). PGP serves as a hydrophobic export pump that extrudes cyclosporine (CsA) across the luminal membrane thus preventing CsA absorption. These genetic variants may predict CsA exposure levels in the early posttransplantation period.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Nov
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pubmed:issn |
0041-1345
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
38
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2847-9
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pubmed:meshHeading |
pubmed-meshheading:17112845-Adult,
pubmed-meshheading:17112845-Area Under Curve,
pubmed-meshheading:17112845-Body Weight,
pubmed-meshheading:17112845-Cyclosporine,
pubmed-meshheading:17112845-Female,
pubmed-meshheading:17112845-Humans,
pubmed-meshheading:17112845-Immunosuppressive Agents,
pubmed-meshheading:17112845-Intestinal Absorption,
pubmed-meshheading:17112845-Kidney Transplantation,
pubmed-meshheading:17112845-Male,
pubmed-meshheading:17112845-Middle Aged,
pubmed-meshheading:17112845-P-Glycoprotein,
pubmed-meshheading:17112845-Polymerase Chain Reaction,
pubmed-meshheading:17112845-Polymorphism, Single Nucleotide
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pubmed:year |
2006
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pubmed:articleTitle |
MDR1 C3435T polymorphisms correlate with cyclosporine levels in de novo renal recipients.
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pubmed:affiliation |
Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
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pubmed:publicationType |
Journal Article
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