Linked Life Data

17112803

Source:http://linkedlifedata.com/resource/pubmed/id/17112803

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-11-20
pubmed:abstractText
The adenosine triphosphate-binding cassette (ABC) class transporter ABCC2 (MRP2 [multidrug resistance related protein 2] or cMOAT [canalicular multispecific organic anion transporter]) is involved in the cellular outward transport and elimination of methotrexate. We hypothesized that common genetic variations may contribute to the variability of high-dose methotrexate pharmacokinetics.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-9236
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
468-76
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:17112803-Adolescent, pubmed-meshheading:17112803-Antimetabolites, Antineoplastic, pubmed-meshheading:17112803-Area Under Curve, pubmed-meshheading:17112803-Child, pubmed-meshheading:17112803-Dose-Response Relationship, Drug, pubmed-meshheading:17112803-Female, pubmed-meshheading:17112803-Gene Frequency, pubmed-meshheading:17112803-Germany, pubmed-meshheading:17112803-Half-Life, pubmed-meshheading:17112803-Haplotypes, pubmed-meshheading:17112803-Humans, pubmed-meshheading:17112803-Infusions, Intravenous, pubmed-meshheading:17112803-Male, pubmed-meshheading:17112803-Membrane Transport Proteins, pubmed-meshheading:17112803-Metabolic Clearance Rate, pubmed-meshheading:17112803-Methotrexate, pubmed-meshheading:17112803-Multidrug Resistance-Associated Proteins, pubmed-meshheading:17112803-Multivariate Analysis, pubmed-meshheading:17112803-Polymerase Chain Reaction, pubmed-meshheading:17112803-Polymorphism, Genetic, pubmed-meshheading:17112803-Polymorphism, Single-Stranded Conformational, pubmed-meshheading:17112803-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:17112803-Regression Analysis, pubmed-meshheading:17112803-Sex Factors
pubmed:year
2006
pubmed:articleTitle
High-dose methotrexate in pediatric acute lymphoblastic leukemia: impact of ABCC2 polymorphisms on plasma concentrations.
pubmed:affiliation
Department of Clinical and Experimental Pharmacology and Toxicology, University Medical Center Hamburg-Eppendorf, Hamburg, and Children's Hospital, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen, Germany. t.rau@uke.uni-hamburg.de
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't