Linked Life Data

17112802

Source:http://linkedlifedata.com/resource/pubmed/id/17112802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2006-11-20
pubmed:abstractText
The liver enzyme cytochrome P450 (CYP) 2A6 is primarily responsible for the metabolism of nicotine. Variants in the CYP2A6 gene have been associated with altered nicotine metabolism and with effects on smoking behavior. Our objective was to determine the relationship between variant CYP2A6 genotypes and the disposition and metabolism of nicotine administered intravenously.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0009-9236
pubmed:author
pubmed:issnType
Print
pubmed:volume
80
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
457-67
pubmed:dateRevised
2007-12-3
pubmed:meshHeading
pubmed-meshheading:17112802-Adolescent, pubmed-meshheading:17112802-Adult, pubmed-meshheading:17112802-Aged, pubmed-meshheading:17112802-Alleles, pubmed-meshheading:17112802-Area Under Curve, pubmed-meshheading:17112802-Aryl Hydrocarbon Hydroxylases, pubmed-meshheading:17112802-Cotinine, pubmed-meshheading:17112802-Deuterium, pubmed-meshheading:17112802-Dose-Response Relationship, Drug, pubmed-meshheading:17112802-Ganglionic Stimulants, pubmed-meshheading:17112802-Gene Frequency, pubmed-meshheading:17112802-Glucuronides, pubmed-meshheading:17112802-Half-Life, pubmed-meshheading:17112802-Humans, pubmed-meshheading:17112802-Infusions, Intravenous, pubmed-meshheading:17112802-Isoenzymes, pubmed-meshheading:17112802-Metabolic Clearance Rate, pubmed-meshheading:17112802-Middle Aged, pubmed-meshheading:17112802-Mixed Function Oxygenases, pubmed-meshheading:17112802-Nicotine, pubmed-meshheading:17112802-Polymorphism, Genetic, pubmed-meshheading:17112802-Time Factors, pubmed-meshheading:17112802-Twins
pubmed:year
2006
pubmed:articleTitle
CYP2A6 genotype and the metabolism and disposition kinetics of nicotine.
pubmed:affiliation
Division of Clinical Pharmacology and Experimental Therapeutics, Medical Service, San Francisco General Hospital Medical Center, and Department of Medicine, University of California, San Francisco, San Francisco 94143-1220, USA. nbenowitz@medsfgh.ucsf.edu
pubmed:publicationType
Journal Article, Clinical Trial, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural