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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2007-1-16
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pubmed:abstractText |
The cell viability of human cancer cell lines treated with [5,10-bis(N-methyl-4-pyridyl)-15,20-diphenyl]porphinatoiron(III) (cis-FeMPy(2)P(2)P) has been estimated. The cis-FeMPy(2)P(2)P is a superoxide dismutase (SOD) mimic in vitro that exhibited a significant toxicity in cancer cell lines. This toxicity is rather due to pro-oxidant properties of the iron-porphyrin in vivo. We have demonstrated that there was the relationship between the LD(50) values calculated from the viability of cancer cell lines treated with cis-FeMPy(2)P(2)P and the SOD activities of the cell lines. Furthermore, the inhibition of SOD by antisense S-oligonucleotide increased the cytotoxic effect of cis-FeMPy(2)P(2)P against cancer cells. These results suggest that SOD is a target enzyme for the cell death induced by cis-FeMPy(2)P(2)P as a new class of anticancer agents.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0162-0134
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
101
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
261-6
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pubmed:meshHeading |
pubmed-meshheading:17112592-Base Sequence,
pubmed-meshheading:17112592-Catalase,
pubmed-meshheading:17112592-Cell Death,
pubmed-meshheading:17112592-Cell Line, Tumor,
pubmed-meshheading:17112592-Cisplatin,
pubmed-meshheading:17112592-Enzyme Inhibitors,
pubmed-meshheading:17112592-HeLa Cells,
pubmed-meshheading:17112592-Humans,
pubmed-meshheading:17112592-Iron,
pubmed-meshheading:17112592-Metalloporphyrins,
pubmed-meshheading:17112592-Molecular Mimicry,
pubmed-meshheading:17112592-Molecular Structure,
pubmed-meshheading:17112592-Oligodeoxyribonucleotides, Antisense,
pubmed-meshheading:17112592-Superoxide Dismutase
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pubmed:year |
2007
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pubmed:articleTitle |
Superoxide dismutase as a target enzyme for Fe-porphyrin-induced cell death.
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pubmed:affiliation |
Department of Applied Chemistry, Tokyo Metropolitan University, 1-1 Minami-Osawa, Hachioji, Tokyo 192-0397, Japan. asayama-shoichiro@c.metro-u.ac.jp
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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