|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
2006-11-24
|
|
pubmed:abstractText |
The transcription factor 7-like 2 (TCF7L2) is a critical component of the Wnt/beta-catenin pathway. Aberrant TCF7L2 expression modifies Wnt signaling and mediates oncogenic effects through the upregulation of c-MYC and cyclin D. Genetic alterations in TCF7L2 may therefore affect cancer risk. Recently, TCF7L2 variants, including the microsatellite marker DG10S478 and the nearly perfectly linked SNP rs12233372, were identified to associate with type 2 diabetes.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-10485457,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-10759547,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-10919662,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-11802209,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-11839557,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-12574941,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-13679587,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-14557987,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-15001769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-15550452,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-16107313,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-16381023,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-16415884,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-16936216,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-16959974,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-17031610,
http://linkedlifedata.com/resource/pubmed/commentcorrection/17109766-9875838
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:issn |
1471-2407
|
|
pubmed:author |
|
|
pubmed:issnType |
Electronic
|
|
pubmed:volume |
6
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
268
|
|
pubmed:dateRevised |
2010-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:17109766-Adult,
pubmed-meshheading:17109766-Aged,
pubmed-meshheading:17109766-Aged, 80 and over,
pubmed-meshheading:17109766-Alleles,
pubmed-meshheading:17109766-Breast Neoplasms,
pubmed-meshheading:17109766-Case-Control Studies,
pubmed-meshheading:17109766-Female,
pubmed-meshheading:17109766-Gene Dosage,
pubmed-meshheading:17109766-Humans,
pubmed-meshheading:17109766-Middle Aged,
pubmed-meshheading:17109766-Polymorphism, Genetic,
pubmed-meshheading:17109766-Risk Factors,
pubmed-meshheading:17109766-TCF Transcription Factors,
pubmed-meshheading:17109766-Transcription Factor 7-Like 2 Protein
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Transcription factor 7-like 2 (TCF7L2) variant is associated with familial breast cancer risk: a case-control study.
|
|
pubmed:affiliation |
Helmholtz-University Group Molecular Epidemiology, German Cancer Research Center, DKFZ, Heidelberg, Germany. b.burwinkel@dkfz.de <b.burwinkel@dkfz.de>
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
