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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-19
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pubmed:abstractText |
Genetic variation of the human ABCB1 (P-glycoprotein; MDR1 gene product) efflux transporter is strongly suggested as a determinant factor governing the pharmacokinetics of diverse drugs and xenobiotics. Despite various efforts to associate polymorphisms in ABCB1 to actual clinical effect and transport function, information is still inconsistent or even controversial.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1744-6872
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
16
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
855-61
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:17108809-Alleles,
pubmed-meshheading:17108809-Amino Acid Substitution,
pubmed-meshheading:17108809-Animals,
pubmed-meshheading:17108809-Biological Transport, Active,
pubmed-meshheading:17108809-Cell Line,
pubmed-meshheading:17108809-Cloning, Molecular,
pubmed-meshheading:17108809-Digoxin,
pubmed-meshheading:17108809-Enzyme Inhibitors,
pubmed-meshheading:17108809-Humans,
pubmed-meshheading:17108809-Intestinal Mucosa,
pubmed-meshheading:17108809-Kinetics,
pubmed-meshheading:17108809-Organic Anion Transporters,
pubmed-meshheading:17108809-P-Glycoprotein,
pubmed-meshheading:17108809-Pharmacogenetics,
pubmed-meshheading:17108809-Polymorphism, Single Nucleotide,
pubmed-meshheading:17108809-Rats,
pubmed-meshheading:17108809-Recombinant Proteins,
pubmed-meshheading:17108809-Spodoptera,
pubmed-meshheading:17108809-Verapamil,
pubmed-meshheading:17108809-Vincristine
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pubmed:year |
2006
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pubmed:articleTitle |
In-vitro transport characteristics discriminate wild-type ABCB1 (MDR1) from ALA893SER and ALA893THR polymorphisms.
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pubmed:affiliation |
Institute of Clinical Pharmacology, Charité University Medicine bCenimed GmbH, Center for Individualized Medicine, Clinical Pharmacogenomics, Berlin, Germany.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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