Linked Life Data

17108065

Source:http://linkedlifedata.com/resource/pubmed/id/17108065

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2006-12-15
pubmed:abstractText
Cloretazine (VNP40101M) is a newly synthesized alkylating agent belonging to a novel class of alkylating agents called 1,2-bis(sulfonyl)hydrazines. Agents that belong to this class do not produce vinylating and chloroethylating species, and hence this class of alkylating agents is thought to have minimal systemic toxicity. Cloretazine produces two short-lived active species: 1,2-bis(methylsulfonyl)-1-(2-chloroethyl) hydrazine (a chloroethylating species) and a thiophilic carbamoylating methylisocyanate species. The chloroethylating species preferentially produces lesions at the O(6) position of guanine. The methylisocyanate species may inhibit O(6)-alkylguanine-DNA alkyltransferase, an important mechanism of resistance against alkylating agents. The purpose of this study was to determine the efficacy and tolerability of Cloretazine in patients with recurrent glioblastoma multiforme. The basis for the determination of efficacy was the proportion of patients alive without evidence of disease progression six months after initiation of treatment. Patients with recurrent glioblastoma multiforme received Cloretazine (300 mg/m(2)) intravenously every six weeks. Radiographic response, survival data, and toxicity were assessed. Thirty-two patients were enrolled. Median age was 56 years; 24 patients (75%) were men. At six months, two patients were alive and progression free, so the six-month progression-free survival (PFS) was 6%. The median PFS was 6.3 weeks. There were no objective radiographic responses. Twelve patients had stable disease for at least one cycle, but only two patients received more than three cycles. Nine patients experienced grade 4 thrombocytopenia and three patients experienced grade 4 neutropenia. Cloretazine administered every six weeks was relatively well tolerated, although this schedule has insignificant activity for patients with recurrent glioblastoma multiforme.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-10609557, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-10944597, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-11770297, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-15857610, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-229983, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-2358840, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-2991486, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-346276, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-3513316, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-6321671, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-6690082, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-7001230, http://linkedlifedata.com/resource/pubmed/commentcorrection/17108065-7807189
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1522-8517
pubmed:author
pubmed:issnType
Print
pubmed:volume
9
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
70-4
pubmed:dateRevised
2010-11-18
pubmed:meshHeading
pubmed:year
2007
pubmed:articleTitle
Phase II study of Cloretazine for the treatment of adults with recurrent glioblastoma multiforme.
pubmed:affiliation
Duke University Medical Center, Brain Tumor Center, Department of Surgery, Durham, NC 27710, USA.
pubmed:publicationType
Journal Article, Clinical Trial, Phase II, Research Support, N.I.H., Extramural