rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
2006-12-18
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pubmed:abstractText |
Allelotype studies have suggested that chromosome 1p is frequently lost in thyroid cancers, thus suggesting that there is an important tumor suppressor at this location. RIZ1 (PRDM2), located on 1p36, is a recently described tumor suppressor gene and is a member of the protein methyltransferase superfamily. RIZ1 expression is lost in a variety of tumors, primarily by means of epigenetic mechanisms that involve promoter hypermethylation.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antimetabolites, Antineoplastic,
http://linkedlifedata.com/resource/pubmed/chemical/Azacitidine,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Histone-Lysine N-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Nuclear Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/PRDM2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0008-543X
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pubmed:author |
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pubmed:copyrightInfo |
Copyright 2006 American Cancer Society.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
107
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2752-9
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:17103461-Antimetabolites, Antineoplastic,
pubmed-meshheading:17103461-Azacitidine,
pubmed-meshheading:17103461-Carcinoma,
pubmed-meshheading:17103461-Cell Line, Tumor,
pubmed-meshheading:17103461-DNA Methylation,
pubmed-meshheading:17103461-DNA-Binding Proteins,
pubmed-meshheading:17103461-Epigenesis, Genetic,
pubmed-meshheading:17103461-Gene Expression Regulation, Neoplastic,
pubmed-meshheading:17103461-Histone-Lysine N-Methyltransferase,
pubmed-meshheading:17103461-Humans,
pubmed-meshheading:17103461-Nuclear Proteins,
pubmed-meshheading:17103461-Promoter Regions, Genetic,
pubmed-meshheading:17103461-RNA, Messenger,
pubmed-meshheading:17103461-Thyroid Neoplasms,
pubmed-meshheading:17103461-Transcription Factors
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pubmed:year |
2006
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pubmed:articleTitle |
RIZ1 is epigenetically inactivated by promoter hypermethylation in thyroid carcinoma.
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pubmed:affiliation |
Department of Surgery, Division of Surgical Oncology, University of Iowa, Iowa City, Iowa, USA.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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