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pubmed-article:17101573pubmed:abstractTextThe identification of CARD15 as a susceptibility gene for Crohn's disease (CD) offers new possibilities for patient classification and risk assessment. The purpose of this study was to carry out a CARD15 sequence analysis in a large single-center IBD cohort and to investigate the impact of different genotypes on disease phenotypes.lld:pubmed
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pubmed-article:17101573pubmed:articleTitleHomozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.lld:pubmed
pubmed-article:17101573pubmed:affiliationDepartment of Internal Medicine II, University of Munich, Germany.lld:pubmed
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