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rdf:type |
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lifeskim:mentions |
umls-concept:C0010346,
umls-concept:C0016169,
umls-concept:C0019904,
umls-concept:C0079380,
umls-concept:C0332162,
umls-concept:C0332167,
umls-concept:C0332183,
umls-concept:C0400847,
umls-concept:C0549433,
umls-concept:C0681890,
umls-concept:C0686904,
umls-concept:C1826449,
umls-concept:C1843571,
umls-concept:C1850419,
umls-concept:C1970036,
umls-concept:C2698415
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pubmed:issue |
12
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pubmed:dateCreated |
2006-11-14
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|
pubmed:abstractText |
The identification of CARD15 as a susceptibility gene for Crohn's disease (CD) offers new possibilities for patient classification and risk assessment. The purpose of this study was to carry out a CARD15 sequence analysis in a large single-center IBD cohort and to investigate the impact of different genotypes on disease phenotypes.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0036-5521
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pubmed:author |
pubmed-author:BrandStephanS,
pubmed-author:DambacherJuliaJ,
pubmed-author:GökeBurkhardB,
pubmed-author:HerrmannKarinK,
pubmed-author:HofbauerKatrinK,
pubmed-author:LohsePeterP,
pubmed-author:OchsenkühnThomasT,
pubmed-author:PfennigSimoneS,
pubmed-author:SackmannMichaelM,
pubmed-author:SchnitzlerFabianF,
pubmed-author:SeidererJuliaJ,
pubmed-author:StaudingerTanjaT,
pubmed-author:TillackCorneliaC
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pubmed:issnType |
Print
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pubmed:volume |
41
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pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
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pubmed:pagination |
1421-32
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pubmed:meshHeading |
pubmed-meshheading:17101573-Adolescent,
pubmed-meshheading:17101573-Adult,
pubmed-meshheading:17101573-Age of Onset,
pubmed-meshheading:17101573-Aged,
pubmed-meshheading:17101573-Aged, 80 and over,
pubmed-meshheading:17101573-Child,
pubmed-meshheading:17101573-Colitis,
pubmed-meshheading:17101573-Colitis, Ulcerative,
pubmed-meshheading:17101573-Crohn Disease,
pubmed-meshheading:17101573-Female,
pubmed-meshheading:17101573-Frameshift Mutation,
pubmed-meshheading:17101573-Genotype,
pubmed-meshheading:17101573-Homozygote,
pubmed-meshheading:17101573-Humans,
pubmed-meshheading:17101573-Ileal Diseases,
pubmed-meshheading:17101573-Intestinal Fistula,
pubmed-meshheading:17101573-Male,
pubmed-meshheading:17101573-Middle Aged,
pubmed-meshheading:17101573-Nod2 Signaling Adaptor Protein,
pubmed-meshheading:17101573-Recurrence
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pubmed:year |
2006
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pubmed:articleTitle |
Homozygosity for the CARD15 frameshift mutation 1007fs is predictive of early onset of Crohn's disease with ileal stenosis, entero-enteral fistulas, and frequent need for surgical intervention with high risk of re-stenosis.
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pubmed:affiliation |
Department of Internal Medicine II, University of Munich, Germany.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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