|
rdf:type |
|
|
lifeskim:mentions |
umls-concept:C0010762,
umls-concept:C0013081,
umls-concept:C0019080,
umls-concept:C0026336,
umls-concept:C0035820,
umls-concept:C0160390,
umls-concept:C0205054,
umls-concept:C0243026,
umls-concept:C0597298,
umls-concept:C0871261,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911692
|
|
pubmed:issue |
1
|
|
pubmed:dateCreated |
2006-12-12
|
|
pubmed:abstractText |
The "double-hit" model of hemorrhage and sepsis mimics the critically ill patient admitted to the surgical intensive care unit. Although the protein expression of a cytochrome (CYP) P-450 isoform CYP1A2 is reduced in the late stage of sepsis, the effect of hemorrhage on CYP isoforms and the anti-inflammatory nuclear receptor peroxisome proliferator-activated receptor-gamma (PPAR-gamma) has not been investigated. We hypothesized that hemorrhage down-regulates CYP isoforms and PPAR-gamma in the liver, which plays an important role in producing tissue injury and proinflammatory responses after the subsequent sepsis (i.e., double-hit).
|
|
pubmed:grant |
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Alanine Transaminase,
http://linkedlifedata.com/resource/pubmed/chemical/Aryl Hydrocarbon Hydroxylases,
http://linkedlifedata.com/resource/pubmed/chemical/Aspartate Aminotransferases,
http://linkedlifedata.com/resource/pubmed/chemical/CYP2C11 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochrome P-450 CYP1A2,
http://linkedlifedata.com/resource/pubmed/chemical/Cytochromes,
http://linkedlifedata.com/resource/pubmed/chemical/Interleukin-6,
http://linkedlifedata.com/resource/pubmed/chemical/Lactic Acid,
http://linkedlifedata.com/resource/pubmed/chemical/PPAR gamma,
http://linkedlifedata.com/resource/pubmed/chemical/Steroid 16-alpha-Hydroxylase,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factor-alpha,
http://linkedlifedata.com/resource/pubmed/chemical/cytochrome P-448
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jan
|
|
pubmed:issn |
0022-4804
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
137
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
46-52
|
|
pubmed:dateRevised |
2009-11-19
|
|
pubmed:meshHeading |
pubmed-meshheading:17101152-Alanine Transaminase,
pubmed-meshheading:17101152-Animals,
pubmed-meshheading:17101152-Aryl Hydrocarbon Hydroxylases,
pubmed-meshheading:17101152-Aspartate Aminotransferases,
pubmed-meshheading:17101152-Cytochrome P-450 CYP1A2,
pubmed-meshheading:17101152-Cytochromes,
pubmed-meshheading:17101152-Disease Models, Animal,
pubmed-meshheading:17101152-Down-Regulation,
pubmed-meshheading:17101152-Gene Expression Regulation, Enzymologic,
pubmed-meshheading:17101152-Interleukin-6,
pubmed-meshheading:17101152-Lactic Acid,
pubmed-meshheading:17101152-Liver,
pubmed-meshheading:17101152-Liver Diseases,
pubmed-meshheading:17101152-Male,
pubmed-meshheading:17101152-PPAR gamma,
pubmed-meshheading:17101152-Rats,
pubmed-meshheading:17101152-Rats, Sprague-Dawley,
pubmed-meshheading:17101152-Sepsis,
pubmed-meshheading:17101152-Shock, Hemorrhagic,
pubmed-meshheading:17101152-Steroid 16-alpha-Hydroxylase,
pubmed-meshheading:17101152-Tumor Necrosis Factor-alpha
|
|
pubmed:year |
2007
|
|
pubmed:articleTitle |
Downregulation of hepatic cytochrome P-450 isoforms and PPAR-gamma: their role in hepatic injury and proinflammatory responses in a double-hit model of hemorrhage and sepsis.
|
|
pubmed:affiliation |
Department of Surgery, North Shore University Hospital and Long Island Jewish Medical Center, Manhasset, New York 11030, USA.
|
|
pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
|
